| Gene Symbol |
IRGM
|
| Entrez Gene |
345611
|
| Alt Symbol |
IFI1, IRGM1, LRG-47, LRG47
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
immunity-related GTPase family, M
|
| Other Description |
LPS-stimulated RAW 264.7 macrophage protein 47 homolog|LRG-47-like protein|immunity-related GTPase family M protein|immunity-related GTPase family, M1|interferon-inducible protein 1
|
| Swissprots |
B3VEX0 A1A4Y4
|
| Accessions |
A1A4Y4 ACO88909 BAJ13476 BAJ13477 BC038539 BC128167 AAI28168 BC128168 AAI28169 EU742619 ACF21844 XM_011537641 XP_011535943 XR_944324 NM_001145805 NP_001139277
|
| Function |
Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}. Cell projection, phagocytic cup {ECO:0000250}. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes. {ECO:0000269|PubMed:16888103, ECO:0000269|PubMed:17554261}.
|
| Top Pathways |
Toxoplasmosis
|