IRGM

Gene Symbol	IRGM
Entrez Gene	345611
Alt Symbol	IFI1, IRGM1, LRG-47, LRG47
Species	Human
Gene Type	protein-coding
Description	immunity-related GTPase family, M
Other Description	LPS-stimulated RAW 264.7 macrophage protein 47 homolog|LRG-47-like protein|immunity-related GTPase family M protein|immunity-related GTPase family, M1|interferon-inducible protein 1
Swissprots	B3VEX0 A1A4Y4
Accessions	A1A4Y4 ACO88909 BAJ13476 BAJ13477 BC038539 BC128167 AAI28168 BC128168 AAI28169 EU742619 ACF21844 XM_011537641 XP_011535943 XR_944324 NM_001145805 NP_001139277
Function	Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). {ECO:0000250}.
Subcellular Location	Golgi apparatus membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}. Cell projection, phagocytic cup {ECO:0000250}. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi. {ECO:0000250}.
Tissue Specificity	Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes. {ECO:0000269|PubMed:16888103, ECO:0000269|PubMed:17554261}.
Top Pathways	Toxoplasmosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IRGM peptide - ab105483 from Abcam Category Peptide

Human IRGM protein fragment - ab137153 from Abcam Category Protein Source E. coli Species Human

IRGM peptide - ab115829 from Abcam Category Peptide

IRGM / LRG-47 Antibody Blocking Peptide - LS-E774 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRGM / LRG-47 Antibody Blocking Peptide - LS-E30475 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IRGM / LRG-47 Antibody Blocking Peptide - LS-E30476 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IRGM Partial Recombinant Protein - H00345611-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human IRGM Protein - NBP2-23131 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

IRGM Blocking Peptide - NBP1-76890PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

IRGM Blocking Peptide - NBP1-76377PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

IRGM-Antibody-C-term-Blocking-peptide - BP11128b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IRGM Protein - GTX118613-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

IRGM Peptide - GTX85038-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

IRGM Peptide - GTX85039-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Human IRGM protein - orb168677 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

IRGM protein (His tag) - 80R-2611 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

IRGM, 23-181aa, Human, His tag, E.coli - 01-P1833 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

IRGM Peptide - 4543P from ProSci Category Peptide Species Human

IRGM Peptide - 4545P from ProSci Category Peptide Species Human

IRGM fusion protein - ag18528 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

IRGM fusion protein - Ag18631 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

IRGM Human - PRPS-1309 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human immunity-related GTPase family, M, His-tagged - IRGM-394H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Immunity-related GTPase family M protein(IRGM) - CSB-YP011827HU CSB-EP011827HU CSB-BP011827HU CSB-MP011827HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

IRGM, 23-181aa, Human, His tag, E.coli (Denatured) - ATGP1833 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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