IRGM

Gene Symbol IRGM
Entrez Gene 345611
Alt Symbol IFI1, IRGM1, LRG-47, LRG47
Species Human
Gene Type protein-coding
Description immunity-related GTPase family, M
Other Description LPS-stimulated RAW 264.7 macrophage protein 47 homolog|LRG-47-like protein|immunity-related GTPase family M protein|immunity-related GTPase family, M1|interferon-inducible protein 1
Swissprots B3VEX0 A1A4Y4
Accessions A1A4Y4 ACO88909 BAJ13476 BAJ13477 BC038539 BC128167 AAI28168 BC128168 AAI28169 EU742619 ACF21844 XM_011537641 XP_011535943 XR_944324 NM_001145805 NP_001139277
Function Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). {ECO:0000250}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}. Cell projection, phagocytic cup {ECO:0000250}. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi. {ECO:0000250}.
Tissue Specificity Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes. {ECO:0000269|PubMed:16888103, ECO:0000269|PubMed:17554261}.
Top Pathways Toxoplasmosis

IRGM (K-13) - sc-168201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IRGM (S-14) - sc-168202 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IRGM (S-14): sc-168202. Western blot analysis of IRGM expression in AML-193 whole cell lysate.

Anti-IRGM antibody - ab69494 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of ab69494 staining in normal human hippocampus formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab69494, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-IRGM antibody - ab69495 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of IRGM in Human Brain cells using ab69495 at 20 ug/ml.

Anti-IRGM antibody - ab93901 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IRGM antibody (ab93901) at 1 µg/mlLane 1 : Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276)Lane 2 : Colon tissue lysate (Human) Tissue Lysate - adult normal tissue (ab30051)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IRGM antibody - ab118569 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Colon (formalin-fixed, paraffin-embedded) stained with IRGM antibody ab118569 at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-IRGM / LRG-47 Antibody - LS-C164431 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Mouse Irgm1 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The IRGM1 antibody detected the IRGM1 protein (arrow).

Anti-IRGM / LRG-47 Antibody (aa151-179, AP) - LS-C236644 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRGM / LRG-47 Antibody (aa151-179, Biotin) - LS-C236645 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRGM / LRG-47 Antibody (aa151-179, FITC) - LS-C236646 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRGM / LRG-47 Antibody (aa151-179, PE) - LS-C236648 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRGM / LRG-47 Antibody (aa151-179, Azide-free, HRP) - LS-C249282 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRGM / LRG-47 Antibody (N-Terminus) - LS-C53283 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 50 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of IRGM in Rat brain lysate with IRGM antibody at (A) 1 and (B) 2 ug/ml.

Anti-IRGM / LRG-47 Antibody (aa158-186) - LS-C322273 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRGM / LRG-47 Antibody (aa151-179) - LS-C165292 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
IRGM Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-IRGM / LRG-47 Antibody - LS-C164430 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Mouse Irgm1 western blot of mouse brain tissue lysates (35 ug/lane). The IRGM1 antibody detected the Irgm1 protein (arrow).

Anti-IRGM / LRG-47 Antibody (aa151-179, APC) - LS-C236643 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRGM / LRG-47 Antibody (Internal) IHC-plus™ - LS-B2732 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IRGM antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2732 concentration 5 ug/ml.

IRGM Antibody - NBP1-76890 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IRGM Antibody [NBP1-76890] - Analysis in human brain lysate with antibody at (A) 1 and (B) 2 ug/mL.

IRGM Antibody - NBP1-50287 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IRGM Antibody [NBP1-50287] - Western blot analysis of IRGM in human brain lysate with IRGM antibody at (A) 1 and (B) 2 ug/ml.

IRGM Antibody - NBP1-76377 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IRGM Antibody [NBP1-76377] - Rat brain lysate with IRGM antibody at (A) 1 and (B) 2 ug/ml.

IRGM Polyclonal Antibody - bs-4015R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IRGM (ab1) antibody produced in rabbit - PRS4543 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-IRGM: <B>Cat. No. PRS4543</B> Western blot analysis of IRGM in Rat brain lysate with IRGM antibody at (A) 1 and (B) 2 μg/mL.

ANTI-IRGM(C-TERMINAL) antibody produced in rabbit - SAB1307004 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-IRGM (C-term): <B>Cat. No. SAB1307004</B>: IRGM Antibody (C-term) western blot analysis in HepG2 cell line lysates (35 μg/lane).

Anti-IRGM (ab2) antibody produced in rabbit - PRS4545 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-IRGM: <B>Cat. No. PRS4545</B> Immunohistochemistry of IRGM in human brain with IRGM antibody at 5 μg/mL.
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