FKBP8

Gene Symbol FKBP8
Entrez Gene 23770
Alt Symbol FKBP38, FKBPr38
Species Human
Gene Type protein-coding
Description FK506 binding protein 8, 38kDa
Other Description 38 kDa FK506-binding protein|38 kDa FKBP|FK506-binding protein 8 (38kD)|FKBP-38|FKBP-8|PPIase FKBP8|hFKBP38|peptidyl-prolyl cis-trans isomerase FKBP8|rotamase
Swissprots Q53GU3 C8C9T5 Q7Z349 Q86YK6 Q14318
Accessions AAC28753 EAW84709 EAW84710 EAW84711 Q14318 AK026952 AK300571 BAH13306 AK313363 BAG36163 AL042208 AL555689 AM392905 CAL37783 AY225339 AAO39020 AY278607 AAQ84561 BC009966 AAH09966 BM719161 BM790404 BQ953871 BU752982 BX538124 CAD98028 BX647405 BX647720 DB471984 DQ893085 ABM84011 DQ896353 ABM87352 GQ372970 ACU65096 XM_011527862 XP_011526164 XM_011527863 XP_011526165 XM_011527864 XP_011526166 NM_001308373 NP_001295302 NM_012181 NP_036313
Function Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.
Subcellular Location Isoform 1: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side.
Tissue Specificity Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. {ECO:0000269|PubMed:18385096}.

FKBP8 (C-10) - sc-166607 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FKBP8 (C-10): sc-166607. Western blot analysis of FKBP8 expression in HeLa (A) and HS 181.Tes (B) whole cell lysates.

FKBP8 (H-220) - sc-66894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FKBP8 (H-220): sc-66894. Western blot analysis of FKBP8 expression in non-transfected: sc-117752 (A) and mouse FKBP8 transfected: sc-120281 (B) 293T whole cell lysates.

FKBP8 (N-12) - sc-46333 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

FKBP8 (N-13) - sc-46334 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FKBP38 antibody - ab24450 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Human penile tissue, staining FKBP38 with ab24450.Tissue was fixed with paraformaldehyde and blocked with blocking reagent for 2 hours; antigen retrieval was by heat mediation. Samples were incubated with primary antibody (1/1000 in diluent) for 18 hours. An undiluted HRP-conjugated anti-rabbit polyclonal IgG was used as the secondary antibody. See Abreview

Anti-FKBP38 antibody - ab90530 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FKBP38 antibody (ab90530) at 1 µg/ml + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-FKBP38 antibody - ab191379 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling FKBP38 with ab191379 at 7.5 µg/ml.

Anti-FKBP38 antibody - ab167251 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-FKBP38 antibody (ab167251) at 1 µgLane 1 : FKBP38 transfected 293T cell lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-FKBP38 antibody [EPR7441(2)] - ab129113 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7441(2)
All lanes : Anti-FKBP38 antibody [EPR7441(2)] (ab129113) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLane 3 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-FKBP38 / FKBP8 Antibody (N-Terminus, clone EPR7441(2)) - LS-C154394 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7441(2)
Immunofluorescent staining of HeLa cells using anti-FKBP8 / FKBP38 antibody.

Anti-FKBP38 / FKBP8 Antibody (aa93-339) - LS-C293960 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant FKBP38 / FKBP8.

Anti-FKBP38 / FKBP8 Antibody (aa42-276) IHC-plus™ - LS-B10769 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-FKBP38 / FKBP8 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10769 concentration 7.5 ug/ml.

Anti-FKBP38 / FKBP8 Antibody (aa110-329) - LS-C293958 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant FKBP38 / FKBP8.

Anti-FKBP38 / FKBP8 Antibody - LS-C331395 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Jurkat cells lines, using FKBP8 antibody.

Anti-FKBP38 / FKBP8 Antibody (aa199-226) - LS-C166168 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
With HepG2 cell line lysate, the resolved proteins were electrophoretically transferred to PVDF membrane and incubated sequentially with primary antibody FKBP38 (1:1000, 4 degrees C overnight ) and horseradish peroxidase-conjugated second antibody. After washing, the bound antibody complex was detected using an ECL chemiluminescence reagent and XAR film (Kodak).

Anti-FKBP38 / FKBP8 Antibody (aa93-339) - LS-C314307 from LifeSpan Bioscience

Prices $415.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Western blot of recombinant FKBP38 / FKBP8.

Anti-FKBP38 / FKBP8 Antibody - LS-C346220 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of A549 cell using FKBP8 antibody. Blue: DAPI for nuclear staining.

Anti-FKBP38 / FKBP8 Antibody (aa1-325) - LS-C36346 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-FKBP38 / FKBP8 Antibody (aa335-349) - LS-C87283 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FKBP38 / FKBP8 Antibody (aa199-226, AP) - LS-C207030 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKBP38 / FKBP8 Antibody (aa199-226, APC) - LS-C207031 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKBP38 / FKBP8 Antibody (aa199-226, Biotin) - LS-C207032 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKBP38 / FKBP8 Antibody (aa199-226, FITC) - LS-C207033 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKBP38 / FKBP8 Antibody (aa199-226, Azide-free, HRP) - LS-C207034 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKBP38 / FKBP8 Antibody (aa199-226, PE) - LS-C207035 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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