Gene Symbol | FKBP8 |
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Entrez Gene | 23770 |
Alt Symbol | FKBP38, FKBPr38 |
Species | Human |
Gene Type | protein-coding |
Description | FK506 binding protein 8, 38kDa |
Other Description | 38 kDa FK506-binding protein|38 kDa FKBP|FK506-binding protein 8 (38kD)|FKBP-38|FKBP-8|PPIase FKBP8|hFKBP38|peptidyl-prolyl cis-trans isomerase FKBP8|rotamase |
Swissprots | Q53GU3 C8C9T5 Q7Z349 Q86YK6 Q14318 |
Accessions | AAC28753 EAW84709 EAW84710 EAW84711 Q14318 AK026952 AK300571 BAH13306 AK313363 BAG36163 AL042208 AL555689 AM392905 CAL37783 AY225339 AAO39020 AY278607 AAQ84561 BC009966 AAH09966 BM719161 BM790404 BQ953871 BU752982 BX538124 CAD98028 BX647405 BX647720 DB471984 DQ893085 ABM84011 DQ896353 ABM87352 GQ372970 ACU65096 XM_011527862 XP_011526164 XM_011527863 XP_011526165 XM_011527864 XP_011526166 NM_001308373 NP_001295302 NM_012181 NP_036313 |
Function | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}. |
Subcellular Location | Isoform 1: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side. |
Tissue Specificity | Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. {ECO:0000269|PubMed:18385096}. |
FKBP8 CRISPR/Cas9 KO Plasmid (h) - sc-403075 from Santa Cruz Biotechnology
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FKBP8 HDR Plasmid (h) - sc-403075-HDR from Santa Cruz Biotechnology
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FKBP8 Double Nickase Plasmid (h) - sc-403075-NIC from Santa Cruz Biotechnology
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FKBP8 Double Nickase Plasmid (h2) - sc-403075-NIC-2 from Santa Cruz Biotechnology
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FKBP8 CRISPR Activation Plasmid (h) - sc-403075-ACT from Santa Cruz Biotechnology
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FKBP8 CRISPR Activation Plasmid (h2) - sc-403075-ACT-2 from Santa Cruz Biotechnology
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FKBP8 Lentiviral Activation Particles (h) - sc-403075-LAC from Santa Cruz Biotechnology
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FKBP8 Lentiviral Activation Particles (h2) - sc-403075-LAC-2 from Santa Cruz Biotechnology
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FKBP8 siRNA (h) - sc-45637 from Santa Cruz Biotechnology
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FKBP8 shRNA Plasmid (h) - sc-45637-SH from Santa Cruz Biotechnology
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FKBP8 shRNA (h) Lentiviral Particles - sc-45637-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU106541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1022 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1022 from Sigma-Aldrich
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FKBP8 siRNA (Human) - CRH8458 from Cohesion Biosciences
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FKBP8 - MBS8203315 from MyBioSource
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shRNA set against Human FKBP8 (NM_012181.3) - SHH295301 from Creative biogene
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shRNA set against Human FKBP8(NM_012181.3) - SHH060833 from Creative biogene
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FKBP8 shRNA Plasmid (Human) - CHH8458 from Cohesion Biosciences
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FKBP8 miRNA 3'UTR clone - MiUTR1H-03665 from Creative biogene
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