FKBP8

Gene Symbol FKBP8
Entrez Gene 23770
Alt Symbol FKBP38, FKBPr38
Species Human
Gene Type protein-coding
Description FK506 binding protein 8, 38kDa
Other Description 38 kDa FK506-binding protein|38 kDa FKBP|FK506-binding protein 8 (38kD)|FKBP-38|FKBP-8|PPIase FKBP8|hFKBP38|peptidyl-prolyl cis-trans isomerase FKBP8|rotamase
Swissprots Q53GU3 C8C9T5 Q7Z349 Q86YK6 Q14318
Accessions AAC28753 EAW84709 EAW84710 EAW84711 Q14318 AK026952 AK300571 BAH13306 AK313363 BAG36163 AL042208 AL555689 AM392905 CAL37783 AY225339 AAO39020 AY278607 AAQ84561 BC009966 AAH09966 BM719161 BM790404 BQ953871 BU752982 BX538124 CAD98028 BX647405 BX647720 DB471984 DQ893085 ABM84011 DQ896353 ABM87352 GQ372970 ACU65096 XM_011527862 XP_011526164 XM_011527863 XP_011526165 XM_011527864 XP_011526166 NM_001308373 NP_001295302 NM_012181 NP_036313
Function Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.
Subcellular Location Isoform 1: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side.
Tissue Specificity Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. {ECO:0000269|PubMed:18385096}.

FKBP8-Over-expression-Lysate - LY14038a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag FKBP8 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FKBP8 gene.

FKBP8 293T Cell Transient Overexpression Lysate(Denatured) - H00023770-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

FKBP8 overexpression lysate - LY415928 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

FKBP8 293 Cell Lysate - 407477 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

FKBP38 Overexpression Lysate (Denatured) - H00023770-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
FKBP8 transfected lysate.

FKBP8 (h4): 293T Lysate - sc-158511 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

FKBP8 Over-expression Lysate Product - GWB-DA81A6 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

FKBP38 Overexpression Lysate (Native) - NBP2-10362 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: FKBP38 Overexpression Lysate (Adult Normal) [NBP2-10362] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FKBP38.

Panoply™ Human FKBP8 Knockdown Stable Cell Line - CSC-DC005769 from Creative biogene

Category Cell Line
Species Human
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