| Gene Symbol |
RALBP1
|
| Entrez Gene |
10928
|
| Alt Symbol |
RIP1, RLIP1, RLIP76
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ralA binding protein 1
|
| Other Description |
76 kDa Ral-interacting protein|DNP-SG ATPase|dinitrophenyl S-glutathione ATPase|ral-interacting protein 1|ralA-binding protein 1
|
| Swissprots |
D3DUI0 Q15311
|
| Accessions |
EAX01601 EAX01602 EAX01603 EAX01604 EAX01605 Q15311 AB209924 BAD93161 AK300845 BAG62496 AY517554 AAT44527 BC013126 AAH13126 BF794440 BQ224100 BQ674032 BX352266 DQ891604 ABM82530 EU176588 ABW03389 L42542 AAB00103 NM_006788 NP_006779
|
| Function |
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. {ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:7673236}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:11437348}; Peripheral membrane protein {ECO:0000269|PubMed:11437348}.
|
| Tissue Specificity |
Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. {ECO:0000269|PubMed:11437348}.
|
| Top Pathways |
Pancreatic cancer
|
![Western Blot: RALBP1 Overexpression Lysate (Adult Normal) [NBL1-15132] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RALBP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5552_RALBP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15132-img0002.jpg)