Gene Symbol | RALBP1 |
---|---|
Entrez Gene | 10928 |
Alt Symbol | RIP1, RLIP1, RLIP76 |
Species | Human |
Gene Type | protein-coding |
Description | ralA binding protein 1 |
Other Description | 76 kDa Ral-interacting protein|DNP-SG ATPase|dinitrophenyl S-glutathione ATPase|ral-interacting protein 1|ralA-binding protein 1 |
Swissprots | D3DUI0 Q15311 |
Accessions | EAX01601 EAX01602 EAX01603 EAX01604 EAX01605 Q15311 AB209924 BAD93161 AK300845 BAG62496 AY517554 AAT44527 BC013126 AAH13126 BF794440 BQ224100 BQ674032 BX352266 DQ891604 ABM82530 EU176588 ABW03389 L42542 AAB00103 NM_006788 NP_006779 |
Function | Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. {ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:7673236}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:11437348}; Peripheral membrane protein {ECO:0000269|PubMed:11437348}. |
Tissue Specificity | Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. {ECO:0000269|PubMed:11437348}. |
Top Pathways | Pancreatic cancer |