Gene Symbol | RALBP1 |
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Entrez Gene | 10928 |
Alt Symbol | RIP1, RLIP1, RLIP76 |
Species | Human |
Gene Type | protein-coding |
Description | ralA binding protein 1 |
Other Description | 76 kDa Ral-interacting protein|DNP-SG ATPase|dinitrophenyl S-glutathione ATPase|ral-interacting protein 1|ralA-binding protein 1 |
Swissprots | D3DUI0 Q15311 |
Accessions | EAX01601 EAX01602 EAX01603 EAX01604 EAX01605 Q15311 AB209924 BAD93161 AK300845 BAG62496 AY517554 AAT44527 BC013126 AAH13126 BF794440 BQ224100 BQ674032 BX352266 DQ891604 ABM82530 EU176588 ABW03389 L42542 AAB00103 NM_006788 NP_006779 |
Function | Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. {ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:7673236}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:11437348}; Peripheral membrane protein {ECO:0000269|PubMed:11437348}. |
Tissue Specificity | Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. {ECO:0000269|PubMed:11437348}. |
Top Pathways | Pancreatic cancer |
Human RALBP1 peptide - ab33445 from Abcam
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RALBP1-Antibody-Center-Blocking-peptide - BP12329c from Abgent, a WuXi AppTec company
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RALBP1-AntibodyN-term-Blocking-peptide - BP19392a from Abgent, a WuXi AppTec company
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Human RalA Binding Protein 1 Protein - abx068819 from Abbexa
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Human RalA Binding Protein 1 Protein - abx068820 from Abbexa
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RALBP1 - H00010928-P01-10 from Acris Antibodies
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RALBP1 - H00010928-P01-25 from Acris Antibodies
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RalA Binding Protein 1 (RALBP1), Human - 20-9237 from ARP American Research Products
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RalA Binding Protein 1 (RALBP1), Human - 20-9238 from ARP American Research Products
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RALBP1 fusion protein - Ag3843 from Proteintech Group
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Recombinant Human RALBP1, GST-tagged - RALBP1-2167H from Creative Biomart
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Recombinant RalA Binding Protein 1 (RALBP1) - RPH265Hu01 from Uscn Life Science Inc.
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Recombinant RalA Binding Protein 1 (RALBP1) - RPH265Hu02 from Uscn Life Science Inc.
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Recombinant RalA Binding Protein 1 (RALBP1) - RPH265Mu01 from Uscn Life Science Inc.
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Recombinant RalA Binding Protein 1 (RALBP1) - RPH265Mu02 from Uscn Life Science Inc.
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Recombinant RalA Binding Protein 1 (RALBP1) - RPH265Ra01 from Uscn Life Science Inc.
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Recombinant Human RalA-binding protein 1(RALBP1) - CSB-YP618981HU CSB-EP618981HU CSB-BP618981HU CSB-MP618981HU from Cusabio
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RALBP1 - TP301524 from Acris Antibodies
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Ral Assay Reagent (Ral BP1, agarose) - 14-415 from EMD Millipore
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RALBP1 Recombinant Protein (OPCD06585) - OPCD06585 from Aviva Systems Biology
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RALBP1 Recombinant Protein (OPCD06587) - OPCD06587 from Aviva Systems Biology
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RalA Binding Protein 1 (RALBP1), Recombinant Protein - MBS2009119 from MyBioSource
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RalA Binding Protein 1 (RALBP1), Recombinant Protein - MBS2010468 from MyBioSource
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RalA-binding protein 1 (RALBP1), Recombinant Protein - MBS1371634 from MyBioSource
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Recombinant Human RALBP1 Protein, His-tagged - RALBP1-706H from Creative Biomart
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