| Gene Symbol |
FZD5
|
| Entrez Gene |
7855
|
| Alt Symbol |
C2orf31, HFZ5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
frizzled class receptor 5
|
| Other Description |
Wnt receptor|frizzled 5, seven transmembrane spanning receptor|frizzled family receptor 5|frizzled-5|fz-5|fzE5|seven-transmembrane receptor frizzled-5
|
| Swissprots |
B2RCZ1 A8K2X1 Q13467 Q53R22
|
| Accessions |
AAY24058 EAW70426 Q13467 AB043702 BAB60959 AK000125 AK024850 AK315338 BAG37738 AL136852 CAB66786 BC035962 BC048322 BC058895 BC095474 BC114346 BC156524 AAI56525 BC172518 AAI72518 BF059357 CR533442 CAG38473 U43318 AAC50385 NM_003468 NP_003459 NM_030804
|
| Function |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. {ECO:0000269|PubMed:10097073}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane and also found at the Golgi. {ECO:0000250}.
|
| Top Pathways |
Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway
|