FZD5
| Gene Symbol | FZD5 |
|---|---|
| Entrez Gene | 7855 |
| Alt Symbol | C2orf31, HFZ5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 5 |
| Other Description | Wnt receptor|frizzled 5, seven transmembrane spanning receptor|frizzled family receptor 5|frizzled-5|fz-5|fzE5|seven-transmembrane receptor frizzled-5 |
| Swissprots | B2RCZ1 A8K2X1 Q13467 Q53R22 |
| Accessions | AAY24058 EAW70426 Q13467 AB043702 BAB60959 AK000125 AK024850 AK315338 BAG37738 AL136852 CAB66786 BC035962 BC048322 BC058895 BC095474 BC114346 BC156524 AAI56525 BC172518 AAI72518 BF059357 CR533442 CAG38473 U43318 AAC50385 NM_003468 NP_003459 NM_030804 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. {ECO:0000269|PubMed:10097073}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane and also found at the Golgi. {ECO:0000250}. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
frizzled-5 CRISPR/Cas9 KO Plasmid (h) - sc-405844 from Santa Cruz Biotechnology
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frizzled-5 HDR Plasmid (h) - sc-405844-HDR from Santa Cruz Biotechnology
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frizzled-5 Double Nickase Plasmid (h) - sc-405844-NIC from Santa Cruz Biotechnology
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frizzled-5 Double Nickase Plasmid (h2) - sc-405844-NIC-2 from Santa Cruz Biotechnology
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frizzled-5 CRISPR Activation Plasmid (h) - sc-405844-ACT from Santa Cruz Biotechnology
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frizzled-5 CRISPR Activation Plasmid (h2) - sc-405844-ACT-2 from Santa Cruz Biotechnology
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frizzled-5 Lentiviral Activation Particles (h) - sc-405844-LAC from Santa Cruz Biotechnology
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frizzled-5 Lentiviral Activation Particles (h2) - sc-405844-LAC-2 from Santa Cruz Biotechnology
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frizzled-5 siRNA (h) - sc-39985 from Santa Cruz Biotechnology
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frizzled-5 shRNA Plasmid (h) - sc-39985-SH from Santa Cruz Biotechnology
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frizzled-5 shRNA (h) Lentiviral Particles - sc-39985-V from Santa Cruz Biotechnology
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Frizzled-5 RNAi - H00007855-R02 from Novus Biologicals
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MISSION® esiRNA - EHU125691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9026 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9026 from Sigma-Aldrich
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FZD5 siRNA (Human) - CRH5297 from Cohesion Biosciences
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FZD5 - MBS8215944 from MyBioSource
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frizzled-5 CRISPR/Cas9 KO Plasmid (h2) - sc-405844-KO-2 from Santa Cruz Biotechnology
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frizzled-5 HDR Plasmid (h2) - sc-405844-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human FZD5 (NM_003468.3) - SHH298109 from Creative biogene
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shRNA set against Human FZD5(NM_003468.3) - SHH072227 from Creative biogene
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Human FZD5 siRNA - orb265799 from Biorbyt
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FZD5 shRNA Plasmid (Human) - CHH5297 from Cohesion Biosciences
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FZD5 miRNA 3'UTR clone - MiUTR1H-03890 from Creative biogene
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