FZD5
| Gene Symbol | FZD5 |
|---|---|
| Entrez Gene | 7855 |
| Alt Symbol | C2orf31, HFZ5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 5 |
| Other Description | Wnt receptor|frizzled 5, seven transmembrane spanning receptor|frizzled family receptor 5|frizzled-5|fz-5|fzE5|seven-transmembrane receptor frizzled-5 |
| Swissprots | B2RCZ1 A8K2X1 Q13467 Q53R22 |
| Accessions | AAY24058 EAW70426 Q13467 AB043702 BAB60959 AK000125 AK024850 AK315338 BAG37738 AL136852 CAB66786 BC035962 BC048322 BC058895 BC095474 BC114346 BC156524 AAI56525 BC172518 AAI72518 BF059357 CR533442 CAG38473 U43318 AAC50385 NM_003468 NP_003459 NM_030804 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. {ECO:0000269|PubMed:10097073}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane and also found at the Golgi. {ECO:0000250}. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
Frizzled5 (D2H2) Rabbit mAb - 5266 from Cell Signaling Technology
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Frizzled5 Antibody - 3795 from Cell Signaling Technology
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frizzled-5 (K-12) - sc-23223 from Santa Cruz Biotechnology
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frizzled-5 (L-12) - sc-23222 from Santa Cruz Biotechnology
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frizzled-5/8 (N-16) - sc-33503 from Santa Cruz Biotechnology
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Anti-Frizzled 5 antibody - ab75234 from Abcam
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Anti-Frizzled 5 antibody - ab14475 from Abcam
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Anti-Frizzled 5 antibody - ab96547 from Abcam
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Anti-Frizzled 5 antibody - ab58177 from Abcam
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Anti-Frizzled 5 antibody - ab115204 from Abcam
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Anti-Frizzled 5 antibody - C-terminal - ab189765 from Abcam
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Anti-Frizzled 5 antibody - N-terminal - ab189761 from Abcam
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Anti-FZD5 / Frizzled 5 Antibody (aa471-500, Azide-free, HRP) - LS-C214428 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody (clone 2D12) - LS-C169125 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody - LS-C311153 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody (aa31-80) - LS-C198984 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody (aa471-500) - LS-C321499 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody (clone 6A3) - LS-C198504 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody (aa467-516) IHC-plus⢠- LS-B5722 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody (Cytoplasmic Domain) IHC-plus⢠- LS-A4284 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody (N-Terminus) IHC-plus⢠- LS-A4273 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody - LS-C6908 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody (aa564-585) - LS-C23726 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody (C-Terminus) - LS-C30356 from LifeSpan Bioscience
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Anti-FZD5 / Frizzled 5 Antibody (aa564-585) - LS-C152730 from LifeSpan Bioscience
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