| Gene Symbol |
MAGI2
|
| Entrez Gene |
9863
|
| Alt Symbol |
ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane associated guanylate kinase, WW and PDZ domain containing 2
|
| Other Description |
activin receptor interacting protein 1|atrophin-1-interacting protein 1|atrophin-1-interacting protein A|membrane-associated guanylate kinase inverted 2|membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
|
| Swissprots |
A7E2C3 Q9NP44 A4D1C1 Q86UL8 O60510 Q9UDU1 Q86UI7 O60434 Q9UDQ5
|
| Accessions |
AAC23438 AAC25530 AAC61488 AAC79151 AAD15413 AAF66080 AAP21886 AAP22360 EAL24194 EAW77021 EAW77022 EAW77023 EAW77024 EAW77025 Q86UL8 AA448362 AA890379 AB014605 BAA31680 AF038563 AAC05370 AK297353 BAH12560 AK297580 BAH12619 AK298988 BAH12916 AK308685 AK309012 BC150277 AAI50278 Z19922 XM_011516718 XP_011515020 XM_011516719 XP_011515021 XM_011516720 XP_011515022 XM_011516721 XP_011515023 XM_011516722 XP_011515024 XM_011516723 XP_011515025 XM_011516724 XP_011515026 XM_011516725 XP_011515027 XM_011516726 XP_011515028 XM_011516727 XP_011515029 XM_011516728 XP_011515030 XM_011516729 XP_011515031 NM_001301128 NP_001288057 NM_012301 NP_036433
|
| Function |
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. {ECO:0000269|PubMed:10760291}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Late endosome {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Specifically expressed in brain. {ECO:0000269|PubMed:9647693}.
|
| Top Pathways |
Tight junction, TNF signaling pathway, Rap1 signaling pathway
|