MAGI2

Gene Symbol MAGI2
Entrez Gene 9863
Alt Symbol ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM
Species Human
Gene Type protein-coding
Description membrane associated guanylate kinase, WW and PDZ domain containing 2
Other Description activin receptor interacting protein 1|atrophin-1-interacting protein 1|atrophin-1-interacting protein A|membrane-associated guanylate kinase inverted 2|membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Swissprots A7E2C3 Q9NP44 A4D1C1 Q86UL8 O60510 Q9UDU1 Q86UI7 O60434 Q9UDQ5
Accessions AAC23438 AAC25530 AAC61488 AAC79151 AAD15413 AAF66080 AAP21886 AAP22360 EAL24194 EAW77021 EAW77022 EAW77023 EAW77024 EAW77025 Q86UL8 AA448362 AA890379 AB014605 BAA31680 AF038563 AAC05370 AK297353 BAH12560 AK297580 BAH12619 AK298988 BAH12916 AK308685 AK309012 BC150277 AAI50278 Z19922 XM_011516718 XP_011515020 XM_011516719 XP_011515021 XM_011516720 XP_011515022 XM_011516721 XP_011515023 XM_011516722 XP_011515024 XM_011516723 XP_011515025 XM_011516724 XP_011515026 XM_011516725 XP_011515027 XM_011516726 XP_011515028 XM_011516727 XP_011515029 XM_011516728 XP_011515030 XM_011516729 XP_011515031 NM_001301128 NP_001288057 NM_012301 NP_036433
Function Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. {ECO:0000269|PubMed:10760291}.
Subcellular Location Cytoplasm {ECO:0000250}. Late endosome {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). {ECO:0000250}.
Tissue Specificity Specifically expressed in brain. {ECO:0000269|PubMed:9647693}.
Top Pathways Tight junction, TNF signaling pathway, Rap1 signaling pathway

MAGI-2 CRISPR/Cas9 KO Plasmid (h) - sc-404260 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGI-2 HDR Plasmid (h) - sc-404260-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGI-2 Double Nickase Plasmid (h) - sc-404260-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGI-2 Double Nickase Plasmid (h2) - sc-404260-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGI-2 CRISPR Activation Plasmid (h) - sc-404260-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGI-2 CRISPR Activation Plasmid (h2) - sc-404260-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGI-2 Lentiviral Activation Particles (h) - sc-404260-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGI-2 Lentiviral Activation Particles (h2) - sc-404260-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGI-2 siRNA (h) - sc-42002 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAGI-2 shRNA Plasmid (h) - sc-42002-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAGI-2 shRNA (h) Lentiviral Particles - sc-42002-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAGI-2 siRNA (m) - sc-42003 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MAGI-2 shRNA Plasmid (m) - sc-42003-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MAGI-2 shRNA (m) Lentiviral Particles - sc-42003-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MAGI2 RNAi - H00009863-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU076621 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1090 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1091 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1092 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN12941 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12941 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MAGI2 siRNA (Human) - CRH6613 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MAGI2(NM_012301.3) - SHH171533 from Creative biogene

Category siRNA
Species Reactivities Human

MAGI2 shRNA Plasmid (Human) - CHH6613 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MAGI2 miRNA 3'UTR clone - MiUTR1H-06023 from Creative biogene

Species Reactivities Human
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