MAGI2

Gene Symbol	MAGI2
Entrez Gene	9863
Alt Symbol	ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM
Species	Human
Gene Type	protein-coding
Description	membrane associated guanylate kinase, WW and PDZ domain containing 2
Other Description	activin receptor interacting protein 1|atrophin-1-interacting protein 1|atrophin-1-interacting protein A|membrane-associated guanylate kinase inverted 2|membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Swissprots	A7E2C3 Q9NP44 A4D1C1 Q86UL8 O60510 Q9UDU1 Q86UI7 O60434 Q9UDQ5
Accessions	AAC23438 AAC25530 AAC61488 AAC79151 AAD15413 AAF66080 AAP21886 AAP22360 EAL24194 EAW77021 EAW77022 EAW77023 EAW77024 EAW77025 Q86UL8 AA448362 AA890379 AB014605 BAA31680 AF038563 AAC05370 AK297353 BAH12560 AK297580 BAH12619 AK298988 BAH12916 AK308685 AK309012 BC150277 AAI50278 Z19922 XM_011516718 XP_011515020 XM_011516719 XP_011515021 XM_011516720 XP_011515022 XM_011516721 XP_011515023 XM_011516722 XP_011515024 XM_011516723 XP_011515025 XM_011516724 XP_011515026 XM_011516725 XP_011515027 XM_011516726 XP_011515028 XM_011516727 XP_011515029 XM_011516728 XP_011515030 XM_011516729 XP_011515031 NM_001301128 NP_001288057 NM_012301 NP_036433
Function	Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. {ECO:0000269|PubMed:10760291}.
Subcellular Location	Cytoplasm {ECO:0000250}. Late endosome {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). {ECO:0000250}.
Tissue Specificity	Specifically expressed in brain. {ECO:0000269|PubMed:9647693}.
Top Pathways	Tight junction, TNF signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AIP1 peptide - ab23125 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human AIP1 protein fragment - ab160689 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

MAGI2 / AIP-1 Antibody Blocking Peptide - LS-E25646 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAGI2 / AIP-1 Antibody Blocking Peptide - LS-E22449 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MAGI2 Protein - H00009863-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MAGI-2 blocking peptide - GTX25946-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

MAGI2 Blocking Peptide - 33R-2344 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AIP1 Peptide - AC21-0477-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MAGI2 / AIP1 - H00009863-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAGI2 / AIP1 - H00009863-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AIP1 Peptide - 45-224P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

MAGI2 fusion protein - Ag18279 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MAGI2, GST-tagged - MAGI2-709H from Creative Biomart Category Protein Source E.coli Species Human

AIP-1 Blocking Peptide - CBP4069 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

MAGI-2 (E255) Peptide - BS2754P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Membrane-associated guanylate kinase, WW and PDZ domain-contai - CSB-YP771436HU CSB-EP771436HU CSB-BP771436HU CSB-MP771436HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MAGI2 / AIP1 - TP322379 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

AIP1/MAGI2, Peptide - MBS426315 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

MAGI2 Recombinant Protein Antigen - NBP1-89261PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

AIP-1 Blocking Peptide - abx162562 from Abbexa Category Peptide Species Human

MAGI2-Blocking-Peptide-C-term - BP21243b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAGI2 Peptide, Human - M34GP09112H from Creative Peptides Category Peptide Source Synthetic. Species Human

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2), partial, Recombinant Protein - MBS1300836 from MyBioSource Category Protein Prices $880.00, $880.00, $1,105.00, $1,105.00, $1,235.00, $1,235.00, $1,690.00, $1,690.00, $1,725.00, $2,440.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human MAGI2 Protein, MYC/DDK-tagged - MAGI2-334H from Creative Biomart Category Protein Source HEK293 Species Human

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