ARHGEF11

Gene Symbol ARHGEF11
Entrez Gene 9826
Alt Symbol GTRAP48, PDZ-RHOGEF
Species Human
Gene Type protein-coding
Description Rho guanine nucleotide exchange factor (GEF) 11
Other Description Rho guanine exchange factor (GEF) 11|RhoA-specific guanine nucleotide exchange factor|RhoGEF glutamate transport modulator|glutamate transporter EAAT4-associated protein 48|rho guanine nucleotide exchange factor 11
Swissprots Q6PFW2 D3DVD0 Q5VY40 O15085
Accessions EAW52892 EAW52893 EAW52894 O15085 AB002378 BAA20834 AK302500 BAH13728 AL832790 BC057394 AAH57394 XM_005245629 XP_005245686 XM_005245633 XP_005245690 XM_006711659 XP_006711722 XM_006711660 XP_006711723 XM_006711661 XP_006711724 XM_006711662 XP_006711725 XM_006711663 XP_006711726 XM_006711664 XP_006711727 XM_006711665 XP_006711728 XM_011510185 XP_011508487 XM_011510186 XP_011508488 XM_011510187 XP_011508489 XM_011510188 XP_011508490 XM_011510189 XP_011508491 XM_011510190 XP_011508492 NM_014784 NP_055599 NM_198236 NP_937879
Function May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10900204}. Membrane {ECO:0000269|PubMed:10900204}. Note=Translocated to the membrane upon stimulation.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10026210}.
Top Pathways Vascular smooth muscle contraction

PDZ-RhoGEF (C-15) - sc-46232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PDZ-RhoGEF (D-9) - sc-166740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDZ-RhoGEF (D-9): sc-166740. Western blot analysis of PDZ-RhoGEF expression in PC-3 whole cell lysate.

PDZ-RhoGEF (C-20) - sc-46233 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDZ-RhoGEF (C-20): sc-46233. Western blot analysis of PDZ-RhoGEF expression in A549 whole cell lysate.

PDZ-RhoGEF (H-300) - sc-67023 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDZ-RhoGEF (H-300): sc-67023. Western blot analysis of PDZ-RhoGEF expression in MDA-MB-435S whole cell lysate.

PDZ-RhoGEF (N-14) - sc-46234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDZ-RhoGEF (N-14): sc-46234. Western blot analysis of PDZ-RhoGEF expression in PC-3 whole cell lysate.

PDZ-RhoGEF (N-16) - sc-46235 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDZ-RhoGEF (N-16): sc-46235. Western blot analysis of PDZ-RhoGEF expression in HeLa whole cell lysate.

Anti-ARHGEF11 antibody - ab110059 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ARHGEF11 antibody (ab110059) at 1/500 dilutionLane 1 : A549 cell extractLane 2 : COLO cell extractLane 3 : COLO cell extract with immunizing peptideLysates/proteins at 30 µg per lane.

Anti-ARHGEF11 antibody - ab130513 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ARHGEF11 antibody (ab130513) at 1/100 dilution + MDA-MB453 cell line lysates at 35 µg

Anti-ARHGEF11 antibody - ab56568 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56568 ARHGEF11 antibody at 1ug/ml.

Anti-ARHGEF11 antibody [2H7] - ab129312 from Abcam

Host Mouse
Clonality Monoclonal
Clone 2H7
ab129312 at 10 &microg/ml staining ARHGEF11 in Human spleen tissue by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-ARHGEF11 Antibody (aa1-50) IHC-plus™ - LS-B1801 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ARHGEF11 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1801 concentration 10 ug/ml.

Anti-ARHGEF11 Antibody (aa604-632, AP) - LS-C251665 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF11 Antibody (aa604-632, APC) - LS-C251666 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF11 Antibody (aa604-632, Biotin) - LS-C251667 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF11 Antibody (aa604-632, Azide-free, HRP) - LS-C251669 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF11 Antibody (aa604-632, FITC) - LS-C251668 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF11 Antibody (aa604-632, PE) - LS-C251671 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF11 Antibody (aa604-632) - LS-C319579 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF11 Antibody (aa605-632) - LS-C156480 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ARHGEF11 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The ARHGEF11 antibody detected the ARHGEF11 protein (arrow).

Anti-ARHGEF11 Antibody (aa125-175) - LS-C286096 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PDZ-RhoGEF by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-PDZ-RhoGEF used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-ARHGEF11 Antibody (clone 2H7) IHC-plus™ - LS-B6382 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2H7
Anti-ARHGEF11 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6382 concentration 10 ug/ml.

Anti-ARHGEF11 Antibody (aa1472-1522) - LS-C286097 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PDZ-RhoGEF by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-PDZ-RhoGEF used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

Anti-ARHGEF11 Antibody (aa1472-1522) - LS-C286792 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PDZ-RhoGEF by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-PDZ-RhoGEF used at a dilution of 1:100.

ARHGEF11 Antibody - NBP2-24517 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal

ARHGEF11 Antibody - NBP1-06553 from Novus Biologicals

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ARHGEF11 Antibody [NBP1-06553] - Whole cell lysate (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. NBP1-06553 used for WB at 0.04 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. PDZ-RhoGEF was also immunoprecipitated by NBP1-06552, which recognizes an upstream epitope.
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