| Gene Symbol |
ARHGEF11
|
| Entrez Gene |
9826
|
| Alt Symbol |
GTRAP48, PDZ-RHOGEF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho guanine nucleotide exchange factor (GEF) 11
|
| Other Description |
Rho guanine exchange factor (GEF) 11|RhoA-specific guanine nucleotide exchange factor|RhoGEF glutamate transport modulator|glutamate transporter EAAT4-associated protein 48|rho guanine nucleotide exchange factor 11
|
| Swissprots |
Q6PFW2 D3DVD0 Q5VY40 O15085
|
| Accessions |
EAW52892 EAW52893 EAW52894 O15085 AB002378 BAA20834 AK302500 BAH13728 AL832790 BC057394 AAH57394 XM_005245629 XP_005245686 XM_005245633 XP_005245690 XM_006711659 XP_006711722 XM_006711660 XP_006711723 XM_006711661 XP_006711724 XM_006711662 XP_006711725 XM_006711663 XP_006711726 XM_006711664 XP_006711727 XM_006711665 XP_006711728 XM_011510185 XP_011508487 XM_011510186 XP_011508488 XM_011510187 XP_011508489 XM_011510188 XP_011508490 XM_011510189 XP_011508491 XM_011510190 XP_011508492 NM_014784 NP_055599 NM_198236 NP_937879
|
| Function |
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10900204}. Membrane {ECO:0000269|PubMed:10900204}. Note=Translocated to the membrane upon stimulation.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:10026210}.
|
| Top Pathways |
Vascular smooth muscle contraction
|