ARHGEF11

Gene Symbol	ARHGEF11
Entrez Gene	9826
Alt Symbol	GTRAP48, PDZ-RHOGEF
Species	Human
Gene Type	protein-coding
Description	Rho guanine nucleotide exchange factor (GEF) 11
Other Description	Rho guanine exchange factor (GEF) 11|RhoA-specific guanine nucleotide exchange factor|RhoGEF glutamate transport modulator|glutamate transporter EAAT4-associated protein 48|rho guanine nucleotide exchange factor 11
Swissprots	Q6PFW2 D3DVD0 Q5VY40 O15085
Accessions	EAW52892 EAW52893 EAW52894 O15085 AB002378 BAA20834 AK302500 BAH13728 AL832790 BC057394 AAH57394 XM_005245629 XP_005245686 XM_005245633 XP_005245690 XM_006711659 XP_006711722 XM_006711660 XP_006711723 XM_006711661 XP_006711724 XM_006711662 XP_006711725 XM_006711663 XP_006711726 XM_006711664 XP_006711727 XM_006711665 XP_006711728 XM_011510185 XP_011508487 XM_011510186 XP_011508488 XM_011510187 XP_011508489 XM_011510188 XP_011508490 XM_011510189 XP_011508491 XM_011510190 XP_011508492 NM_014784 NP_055599 NM_198236 NP_937879
Function	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10900204}. Membrane {ECO:0000269|PubMed:10900204}. Note=Translocated to the membrane upon stimulation.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10026210}.
Top Pathways	Vascular smooth muscle contraction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ARHGEF11 protein fragment - ab160673 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ARHGEF11 Antibody Blocking Peptide - LS-E4581 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ARHGEF11 Protein - H00009826-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ARHGEF11-Antibody-Center-Blocking-Peptide - BP16930c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ARHGEF11 - H00009826-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ARHGEF11 - H00009826-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human Rho guanine nucleotide exchange factor 11(ARHGEF11) ,partial - CSB-YP002043HU CSB-EP002043HU CSB-BP002043HU CSB-MP002043HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ARHGEF11 Peptide - abx164848 from Abbexa Category Peptide Species Human, Mouse, Rat

ARHGEF11 (transcript variant 2) - TP308729 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ARHGEF11 Recombinant Protein Antigen - NBP1-83314PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ARHGEF11 Recombinant Protein Antigen - NBP1-83313PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ARHGEF11 Recombinant Protein Antigen - NBP1-83312PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ARHGEF11 Peptide, Human - M34GP00881H from Creative Peptides Category Peptide Source Synthetic. Species Human

Rho guanine nucleotide exchange factor 11 (ARHGEF11), partial, Recombinant Protein - MBS1236038 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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