ARHGEF11
| Gene Symbol | ARHGEF11 |
|---|---|
| Entrez Gene | 9826 |
| Alt Symbol | GTRAP48, PDZ-RHOGEF |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho guanine nucleotide exchange factor (GEF) 11 |
| Other Description | Rho guanine exchange factor (GEF) 11|RhoA-specific guanine nucleotide exchange factor|RhoGEF glutamate transport modulator|glutamate transporter EAAT4-associated protein 48|rho guanine nucleotide exchange factor 11 |
| Swissprots | Q6PFW2 D3DVD0 Q5VY40 O15085 |
| Accessions | EAW52892 EAW52893 EAW52894 O15085 AB002378 BAA20834 AK302500 BAH13728 AL832790 BC057394 AAH57394 XM_005245629 XP_005245686 XM_005245633 XP_005245690 XM_006711659 XP_006711722 XM_006711660 XP_006711723 XM_006711661 XP_006711724 XM_006711662 XP_006711725 XM_006711663 XP_006711726 XM_006711664 XP_006711727 XM_006711665 XP_006711728 XM_011510185 XP_011508487 XM_011510186 XP_011508488 XM_011510187 XP_011508489 XM_011510188 XP_011508490 XM_011510189 XP_011508491 XM_011510190 XP_011508492 NM_014784 NP_055599 NM_198236 NP_937879 |
| Function | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10900204}. Membrane {ECO:0000269|PubMed:10900204}. Note=Translocated to the membrane upon stimulation. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:10026210}. |
| Top Pathways | Vascular smooth muscle contraction |
PDZ-RhoGEF CRISPR/Cas9 KO Plasmid (h) - sc-403444 from Santa Cruz Biotechnology
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PDZ-RhoGEF HDR Plasmid (h) - sc-403444-HDR from Santa Cruz Biotechnology
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PDZ-RhoGEF Double Nickase Plasmid (h) - sc-403444-NIC from Santa Cruz Biotechnology
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PDZ-RhoGEF Double Nickase Plasmid (h2) - sc-403444-NIC-2 from Santa Cruz Biotechnology
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PDZ-RhoGEF CRISPR Activation Plasmid (h) - sc-403444-ACT from Santa Cruz Biotechnology
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PDZ-RhoGEF CRISPR Activation Plasmid (h2) - sc-403444-ACT-2 from Santa Cruz Biotechnology
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PDZ-RhoGEF Lentiviral Activation Particles (h) - sc-403444-LAC from Santa Cruz Biotechnology
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PDZ-RhoGEF Lentiviral Activation Particles (h2) - sc-403444-LAC-2 from Santa Cruz Biotechnology
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PDZ-RhoGEF siRNA (h) - sc-45823 from Santa Cruz Biotechnology
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PDZ-RhoGEF shRNA Plasmid (h) - sc-45823-SH from Santa Cruz Biotechnology
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PDZ-RhoGEF shRNA (h) Lentiviral Particles - sc-45823-V from Santa Cruz Biotechnology
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ARHGEF11 RNAi - H00009826-R01 from Novus Biologicals
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MISSION® esiRNA - EHU122841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3444 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3444 from Sigma-Aldrich
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ARHGEF11 siRNA (Human) - CRH6581 from Cohesion Biosciences
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ARHGEF11 RNAi - H00009826-R02 from Novus Biologicals
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ARHGEF11 - MBS8215281 from MyBioSource
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shRNA set against Human ARHGEF11 (NM_198236.2) - SHH239702 from Creative biogene
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ARHGEF11 shRNA Plasmid (Human) - CHH6581 from Cohesion Biosciences
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ARHGEF11 miRNA 3'UTR clone - MiUTR3H-07896 from Creative biogene
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ARHGEF11 miRNA 3'UTR clone - MiUTR3H-07897 from Creative biogene
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