Bbc3
| Gene Symbol | Bbc3 |
|---|---|
| Entrez Gene | 170770 |
| Alt Symbol | PUMA, PUMA/JFY1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | BCL2 binding component 3 |
| Other Description | BH3-only|Bcl-2 binding component 3|bcl-2-binding component 3|p53 up-regulated modulator of apoptosis |
| Swissprots | Q99ML1 |
| Accessions | EDL42101 Q99ML1 AF332560 AAK31317 BC044782 AAH44782 BC060370 AAH60370 BC147261 AAI47262 BC147262 AAI47263 XM_006539575 XP_006539638 XM_006539577 XP_006539640 XM_006539578 XP_006539641 XM_006539579 XP_006539642 XM_006539580 XP_006539643 XM_006539581 XP_006539644 XM_006539582 XP_006539645 XM_006539583 XP_006539646 XM_006539584 XP_006539647 NM_133234 NP_573497 |
| Function | Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53 (By similarity). Regulates ER stress-induced neuronal apoptosis. {ECO:0000250, ECO:0000269|PubMed:21159964, ECO:0000269|PubMed:22761832}. |
| Subcellular Location | Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. {ECO:0000250}. |
| Top Pathways | p53 signaling pathway, Huntington's disease, Measles, Hippo signaling pathway |
Bcl-2-binding component 3, Bbc3, Mouse, ELISA Kit - E1909m from ARP American Research Products
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Mouse PUMA ELISA Kit - MP0752 from NeoScientific
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Mouse P53 Upregulated Modulator Of Apoptosis ELISA - E03P0745 from BlueGene Biotech
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Bcl-2-binding component 3, ELISA Kit - MBS288278 from MyBioSource
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Mouse Bbc3 ELISA Kit - E045522 from Biobool
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Mouse PUMA ELISA Kit - E062841 from Biobool
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BBC3 ELISA Kit (Mouse) (OKEH05303) - OKEH05303 from Aviva Systems Biology
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Mouse PUMA ELISA Kit - EMP0752 from ABclonal
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Bcl-2-binding component 3, ELISA Kit - MBS2885452 from MyBioSource
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