Bbc3

Gene Symbol Bbc3
Entrez Gene 170770
Alt Symbol PUMA, PUMA/JFY1
Species Mouse
Gene Type protein-coding
Description BCL2 binding component 3
Other Description BH3-only|Bcl-2 binding component 3|bcl-2-binding component 3|p53 up-regulated modulator of apoptosis
Swissprots Q99ML1
Accessions EDL42101 Q99ML1 AF332560 AAK31317 BC044782 AAH44782 BC060370 AAH60370 BC147261 AAI47262 BC147262 AAI47263 XM_006539575 XP_006539638 XM_006539577 XP_006539640 XM_006539578 XP_006539641 XM_006539579 XP_006539642 XM_006539580 XP_006539643 XM_006539581 XP_006539644 XM_006539582 XP_006539645 XM_006539583 XP_006539646 XM_006539584 XP_006539647 NM_133234 NP_573497
Function Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53 (By similarity). Regulates ER stress-induced neuronal apoptosis. {ECO:0000250, ECO:0000269|PubMed:21159964, ECO:0000269|PubMed:22761832}.
Subcellular Location Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. {ECO:0000250}.
Top Pathways p53 signaling pathway, Huntington's disease, Measles, Hippo signaling pathway

PUMA CRISPR/Cas9 KO Plasmid (m) - sc-431320 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PUMA HDR Plasmid (m) - sc-431320-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PUMA Double Nickase Plasmid (m) - sc-431320-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PUMA Double Nickase Plasmid (m2) - sc-431320-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PUMA CRISPR Activation Plasmid (m) - sc-431320-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PUMA CRISPR Activation Plasmid (m2) - sc-431320-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PUMA Lentiviral Activation Particles (m) - sc-431320-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PUMA Lentiviral Activation Particles (m2) - sc-431320-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PUMA siRNA (m) - sc-37154 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

PUMAα shRNA Plasmid (m) - sc-37154-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

PUMAα shRNA (m) Lentiviral Particles - sc-37154-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU032541 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN27421 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27421 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

BBC3 siRNA (Mouse) - CRN1368 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

BBC3 - MBS828311 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse BBC3 (NM_133234.2) - SHH245078 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse BBC3 siRNA - orb290843 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

BBC3 shRNA Plasmid (Mouse) - CHN1368 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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