| Gene Symbol |
Bbc3
|
| Entrez Gene |
170770
|
| Alt Symbol |
PUMA, PUMA/JFY1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
BCL2 binding component 3
|
| Other Description |
BH3-only|Bcl-2 binding component 3|bcl-2-binding component 3|p53 up-regulated modulator of apoptosis
|
| Swissprots |
Q99ML1
|
| Accessions |
EDL42101 Q99ML1 AF332560 AAK31317 BC044782 AAH44782 BC060370 AAH60370 BC147261 AAI47262 BC147262 AAI47263 XM_006539575 XP_006539638 XM_006539577 XP_006539640 XM_006539578 XP_006539641 XM_006539579 XP_006539642 XM_006539580 XP_006539643 XM_006539581 XP_006539644 XM_006539582 XP_006539645 XM_006539583 XP_006539646 XM_006539584 XP_006539647 NM_133234 NP_573497
|
| Function |
Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53 (By similarity). Regulates ER stress-induced neuronal apoptosis. {ECO:0000250, ECO:0000269|PubMed:21159964, ECO:0000269|PubMed:22761832}.
|
| Subcellular Location |
Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. {ECO:0000250}.
|
| Top Pathways |
p53 signaling pathway, Huntington's disease, Measles, Hippo signaling pathway
|