| Gene Symbol |
AZI2
|
| Entrez Gene |
64343
|
| Alt Symbol |
AZ2, NAP1, TILP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-azacytidine induced 2
|
| Other Description |
5-azacytidine induced gene 2|5-azacytidine-induced protein 2|NAK-associated protein 1|NF-kappa-B-activating kinase-associated protein 1
|
| Swissprots |
C9JB40 A8K3M2 Q9H6S1 Q9BQF1 H7BXU6 Q86W99
|
| Accessions |
AAF22368 AAF22369 CAJ42721 EAW64392 EAW64393 EAW64394 EAW64395 EAW64396 EAW64397 EAW64398 Q9H6S1 AK025592 BAB15182 AK290637 BAF83326 AY151386 AAO05967 BC001139 BC001853 BG777644 BM546093 BM982133 BX327318 BX386357 BX648471 CB995808 CF528511 DA485515 XM_005265392 XP_005265449 XM_005265393 XP_005265450 XM_011534009 XP_011532311 XM_011534010 XP_011532312 XM_011534011 XP_011532313 NM_001134432 NP_001127904 NM_001134433 NP_001127905 NM_001271650 NP_001258579 NM_022461 NP_071906
|
| Function |
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:14560022}.
|
| Tissue Specificity |
Widely expressed. Abundant expression seen in the pancreas and testis. {ECO:0000269|PubMed:14560022}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway
|
![Western Blot: AZI2 Overexpression Lysate (Adult Normal) [NBP2-06437] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AZI2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5003_AZI2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06437-img0001.jpg)