| Gene Symbol | ASGR1 |
|---|---|
| Entrez Gene | 432 |
| Alt Symbol | ASGPR, ASGPR1, CLEC4H1, HL-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | asialoglycoprotein receptor 1 |
| Other Description | C-type lectin domain family 4 member H1|hepatic lectin H1 |
| Swissprots | I3L1X1 P07306 |
| Accessions | EAW90256 EAW90257 EAW90258 P07306 AB070933 BAB83508 AK124286 AK308375 AK308677 BC032130 AAH32130 BM818592 BQ653541 BT019873 AAV38676 CR542052 CAG46849 DQ892030 ABM82956 DQ895221 ABM86147 FJ410292 ACQ90237 M10058 AAA51785 XM_011523860 XP_011522162 XM_011523861 XP_011522163 NM_001197216 NP_001184145 NM_001671 NP_001662 |
| Function | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
| Subcellular Location | Isoform H1a: Membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Expressed exclusively in hepatic parenchymal cells. |
| Top Pathways | Thyroid hormone synthesis |