Gene Symbol | ASGR1 |
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Entrez Gene | 432 |
Alt Symbol | ASGPR, ASGPR1, CLEC4H1, HL-1 |
Species | Human |
Gene Type | protein-coding |
Description | asialoglycoprotein receptor 1 |
Other Description | C-type lectin domain family 4 member H1|hepatic lectin H1 |
Swissprots | I3L1X1 P07306 |
Accessions | EAW90256 EAW90257 EAW90258 P07306 AB070933 BAB83508 AK124286 AK308375 AK308677 BC032130 AAH32130 BM818592 BQ653541 BT019873 AAV38676 CR542052 CAG46849 DQ892030 ABM82956 DQ895221 ABM86147 FJ410292 ACQ90237 M10058 AAA51785 XM_011523860 XP_011522162 XM_011523861 XP_011522163 NM_001197216 NP_001184145 NM_001671 NP_001662 |
Function | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
Subcellular Location | Isoform H1a: Membrane; Single-pass type II membrane protein. |
Tissue Specificity | Expressed exclusively in hepatic parenchymal cells. |
Top Pathways | Thyroid hormone synthesis |
ASGPR1 CRISPR/Cas9 KO Plasmid (h) - sc-400429 from Santa Cruz Biotechnology
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ASGPR1 HDR Plasmid (h) - sc-400429-HDR from Santa Cruz Biotechnology
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ASGPR1 Double Nickase Plasmid (h) - sc-400429-NIC from Santa Cruz Biotechnology
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ASGPR1 Double Nickase Plasmid (h2) - sc-400429-NIC-2 from Santa Cruz Biotechnology
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ASGPR1 CRISPR Activation Plasmid (h) - sc-400429-ACT from Santa Cruz Biotechnology
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ASGPR1 CRISPR Activation Plasmid (h2) - sc-400429-ACT-2 from Santa Cruz Biotechnology
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ASGPR1 Lentiviral Activation Particles (h) - sc-400429-LAC from Santa Cruz Biotechnology
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ASGPR1 Lentiviral Activation Particles (h2) - sc-400429-LAC-2 from Santa Cruz Biotechnology
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ASGPR1 siRNA (h) - sc-29746 from Santa Cruz Biotechnology
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ASGPR1 shRNA Plasmid (h) - sc-29746-SH from Santa Cruz Biotechnology
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ASGPR1 shRNA (h) Lentiviral Particles - sc-29746-V from Santa Cruz Biotechnology
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ASGPR1 RNAi - H00000432-R02 from Novus Biologicals
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MISSION® esiRNA - EHU026291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3594 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3594 from Sigma-Aldrich
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ASGR1 siRNA (Human) - CRH0311 from Cohesion Biosciences
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ASGR1 - MBS8215195 from MyBioSource
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shRNA set against Human ASGR1 (NM_001671.4) - SHH241454 from Creative biogene
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ASGPR1 CRISPR/Cas9 KO Plasmid (h2) - sc-400429-KO-2 from Santa Cruz Biotechnology
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ASGPR1 HDR Plasmid (h2) - sc-400429-HDR-2 from Santa Cruz Biotechnology
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Human ASGR1 siRNA - orb260813 from Biorbyt
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ASGR1 shRNA Plasmid (Human) - CHH0311 from Cohesion Biosciences
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ASGR1 miRNA 3'UTR clone - MiUTR3H-00208 from Creative biogene
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