| Gene Symbol |
ASGR1
|
| Entrez Gene |
432
|
| Alt Symbol |
ASGPR, ASGPR1, CLEC4H1, HL-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
asialoglycoprotein receptor 1
|
| Other Description |
C-type lectin domain family 4 member H1|hepatic lectin H1
|
| Swissprots |
I3L1X1 P07306
|
| Accessions |
EAW90256 EAW90257 EAW90258 P07306 AB070933 BAB83508 AK124286 AK308375 AK308677 BC032130 AAH32130 BM818592 BQ653541 BT019873 AAV38676 CR542052 CAG46849 DQ892030 ABM82956 DQ895221 ABM86147 FJ410292 ACQ90237 M10058 AAA51785 XM_011523860 XP_011522162 XM_011523861 XP_011522163 NM_001197216 NP_001184145 NM_001671 NP_001662
|
| Function |
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
|
| Subcellular Location |
Isoform H1a: Membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Expressed exclusively in hepatic parenchymal cells.
|
| Top Pathways |
Thyroid hormone synthesis
|
![Western Blot: Asialoglycoprotein Receptor 1 Overexpression Lysate (Adult Normal) [NBL1-07762] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Asialoglycoprotein Receptor 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3702_Asialoglycoprotein%2520Receptor%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07762-img0002.jpg)