| Gene Symbol |
DAAM1
|
| Entrez Gene |
23002
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dishevelled associated activator of morphogenesis 1
|
| Other Description |
disheveled-associated activator of morphogenesis 1
|
| Swissprots |
Q8N1Z8 Q8TB39 Q86U34 Q9Y4D1
|
| Accessions |
EAW80747 EAW80748 EAW80749 Q9Y4D1 AB014566 BAA31641 AK021890 BAG51056 AK093813 BAC04230 AK123651 AK291790 BAF84479 BC024781 AAH24781 BC038428 AAH38428 BC064999 AAH64999 BP199650 BQ050640 BX247986 CAD62320 BX648383 XM_005267430 XP_005267487 XM_005267431 XP_005267488 NM_001270520 NP_001257449 NM_014992 NP_055807
|
| Function |
Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. {ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16630611}. Note=Perinuclear.
|
| Tissue Specificity |
Expressed in all tissues examined.
|
| Top Pathways |
Wnt signaling pathway
|