Gene Symbol | DAAM1 |
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Entrez Gene | 23002 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | dishevelled associated activator of morphogenesis 1 |
Other Description | disheveled-associated activator of morphogenesis 1 |
Swissprots | Q8N1Z8 Q8TB39 Q86U34 Q9Y4D1 |
Accessions | EAW80747 EAW80748 EAW80749 Q9Y4D1 AB014566 BAA31641 AK021890 BAG51056 AK093813 BAC04230 AK123651 AK291790 BAF84479 BC024781 AAH24781 BC038428 AAH38428 BC064999 AAH64999 BP199650 BQ050640 BX247986 CAD62320 BX648383 XM_005267430 XP_005267487 XM_005267431 XP_005267488 NM_001270520 NP_001257449 NM_014992 NP_055807 |
Function | Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. {ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16630611}. Note=Perinuclear. |
Tissue Specificity | Expressed in all tissues examined. |
Top Pathways | Wnt signaling pathway |
DAAM1 CRISPR/Cas9 KO Plasmid (h) - sc-403500 from Santa Cruz Biotechnology
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DAAM1 HDR Plasmid (h) - sc-403500-HDR from Santa Cruz Biotechnology
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DAAM1 Double Nickase Plasmid (h) - sc-403500-NIC from Santa Cruz Biotechnology
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DAAM1 Double Nickase Plasmid (h2) - sc-403500-NIC-2 from Santa Cruz Biotechnology
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DAAM1 CRISPR Activation Plasmid (h) - sc-403500-ACT from Santa Cruz Biotechnology
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DAAM1 CRISPR Activation Plasmid (h2) - sc-403500-ACT-2 from Santa Cruz Biotechnology
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DAAM1 Lentiviral Activation Particles (h) - sc-403500-LAC from Santa Cruz Biotechnology
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DAAM1 Lentiviral Activation Particles (h2) - sc-403500-LAC-2 from Santa Cruz Biotechnology
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DAAM1 siRNA (h) - sc-62190 from Santa Cruz Biotechnology
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DAAM1 shRNA Plasmid (h) - sc-62190-SH from Santa Cruz Biotechnology
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DAAM1 shRNA (h) Lentiviral Particles - sc-62190-V from Santa Cruz Biotechnology
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DAAM1 RNAi - H00023002-R01 from Novus Biologicals
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MISSION® esiRNA - EHU084241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6907 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6907 from Sigma-Aldrich
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DAAM1 siRNA (Human) - CRH7923 from Cohesion Biosciences
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DAAM1 - MBS827701 from MyBioSource
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shRNA set against Human DAAM1 (NM_014992.2) - SHH274293 from Creative biogene
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Human DAAM1 siRNA - orb268425 from Biorbyt
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DAAM1 shRNA Plasmid (Human) - CHH7923 from Cohesion Biosciences
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DAAM1 miRNA 3'UTR clone - MiUTR3H-08618 from Creative biogene
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