| Gene Symbol |
SLX1B
|
| Entrez Gene |
79008
|
| Alt Symbol |
GIYD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
|
| Other Description |
GIY-YIG domain-containing protein 1|SLX1A|structure-specific endonuclease subunit SLX1
|
| Swissprots |
Q9BQ83 Q6NTG6 B7ZME1
|
| Accessions |
Q9BQ83 AK027092 BAB15654 AK225436 BC000754 AAH00754 BC000803 AAH00803 BC015990 AAH15990 BC019306 AAH19306 BC069007 AAH69007 BC130545 AAI30546 BC130547 AAI30548 NM_024044 NP_076949 NM_178044 NP_835145
|
| Function |
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. {ECO:0000255|HAMAP-Rule:MF_03100, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
|
| Subcellular Location |
Nucleus {ECO:0000255|HAMAP-Rule:MF_03100, ECO:0000269|PubMed:19596236}.
|
| Top Pathways |
Fanconi anemia pathway
|