SLX1B

Gene Symbol SLX1B
Entrez Gene 79008
Alt Symbol GIYD2
Species Human
Gene Type protein-coding
Description SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
Other Description GIY-YIG domain-containing protein 1|SLX1A|structure-specific endonuclease subunit SLX1
Swissprots Q9BQ83 Q6NTG6 B7ZME1
Accessions Q9BQ83 AK027092 BAB15654 AK225436 BC000754 AAH00754 BC000803 AAH00803 BC015990 AAH15990 BC019306 AAH19306 BC069007 AAH69007 BC130545 AAI30546 BC130547 AAI30548 NM_024044 NP_076949 NM_178044 NP_835145
Function Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. {ECO:0000255|HAMAP-Rule:MF_03100, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Subcellular Location Nucleus {ECO:0000255|HAMAP-Rule:MF_03100, ECO:0000269|PubMed:19596236}.
Top Pathways Fanconi anemia pathway

SLX1 CRISPR/Cas9 KO Plasmid (h) - sc-417764 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLX1 HDR Plasmid (h) - sc-417764-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLX1 Double Nickase Plasmid (h) - sc-417764-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLX1 Double Nickase Plasmid (h2) - sc-417764-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLX1 CRISPR Activation Plasmid (h) - sc-417764-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLX1 CRISPR Activation Plasmid (h2) - sc-417764-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLX1 Lentiviral Activation Particles (h) - sc-417764-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLX1 Lentiviral Activation Particles (h2) - sc-417764-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MISSION® esiRNA - EHU225321 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

SLX1B siRNA (Human) - CRJ2252 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLX1B (NM_024044.3) - SHH412912 from Creative biogene

Category siRNA
Species Reactivities Human

Human SLX1B siRNA - orb272753 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLX1B shRNA Plasmid (Human) - CHJ2252 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLX1B miRNA 3'UTR clone - MiUTR3H-14995 from Creative biogene

Species Reactivities Human

SLX1B miRNA 3'UTR clone - MiUTR3H-14996 from Creative biogene

Species Reactivities Human
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