SLX1B

Gene Symbol	SLX1B
Entrez Gene	79008
Alt Symbol	GIYD2
Species	Human
Gene Type	protein-coding
Description	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
Other Description	GIY-YIG domain-containing protein 1|SLX1A|structure-specific endonuclease subunit SLX1
Swissprots	Q9BQ83 Q6NTG6 B7ZME1
Accessions	Q9BQ83 AK027092 BAB15654 AK225436 BC000754 AAH00754 BC000803 AAH00803 BC015990 AAH15990 BC019306 AAH19306 BC069007 AAH69007 BC130545 AAI30546 BC130547 AAI30548 NM_024044 NP_076949 NM_178044 NP_835145
Function	Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. {ECO:0000255|HAMAP-Rule:MF_03100, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Subcellular Location	Nucleus {ECO:0000255|HAMAP-Rule:MF_03100, ECO:0000269|PubMed:19596236}.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SLX1 full length protein - ab163955 from Abcam Category Protein Source Wheat germ Species Human

Human SLX1 full length protein - ab166568 from Abcam Category Protein Source Wheat germ Species Human

GIYD1 / SLX1 - H00548593-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

GIYD1 / SLX1 - H00548593-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

GIYD2 fusion protein - Ag13094 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human GIYD2, His-tagged - GIYD2-13270H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Structure-specific endonuclease subunit SLX1(SLX1A) - CSB-YP859831HU CSB-EP859831HU CSB-BP859831HU CSB-MP859831HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Structure-specific endonuclease subunit SLX1 (SLX1A), Recombinant Protein - MBS1487592 from MyBioSource Category Protein Prices $1,030.00, $1,030.00, $1,260.00, $1,260.00, $1,590.00, $1,590.00, $2,055.00, $2,055.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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