JTB

Gene Symbol JTB
Entrez Gene 10899
Alt Symbol HJTB, HSPC222, PAR, hJT
Species Human
Gene Type protein-coding
Description jumping translocation breakpoint
Other Description jumping translocation breakpoint protein|prostate androgen-regulated protein|protein JTB
Swissprots Q6IB19 O95442 O76095 Q9P0Q4
Accessions BAA33735 BAA33736 EAW53242 O76095 AB016488 BAA33731 AF115850 AAD09822 AF131797 AAD20045 AF151056 AAF36142 AK312106 BAG35042 BC000499 AAH00499 BC000996 AAH00996 BC001363 AAH01363 BC001667 AAH01667 BC004239 AAH04239 BC019277 AAH19277 BM907938 BT007285 AAP35949 BU527541 CR456985 CAG33266 NM_006694 NP_006685
Function Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
Tissue Specificity Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. {ECO:0000269|PubMed:10321732, ECO:0000269|PubMed:10762645, ECO:0000269|PubMed:17369841, ECO:0000269|PubMed:21225229}.

JTB (T-12) - sc-164719 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-JTB antibody - ab118263 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab118263 stained CACO-2 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab118263 at 1µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-JTB antibody - ab137008 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-JTB antibody (ab137008) at 1/500 dilution + HUVEC cell lysate at 30 µg

Anti-JTB antibody - ab56798 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56798 JTB antibody at 1ug/ml.

Anti-JTB antibody - ab172673 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-JTB antibody (ab172673) at 1 µg/mlLane 1 : JTB transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-JTB / PAR Antibody (aa16-99) - LS-C178678 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-JTB / PAR Antibody (aa10-59) - LS-C291362 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-JTB / PAR Antibody (aa40-89) - LS-C292112 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-JTB / PAR Antibody - LS-C308565 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PAR / Poly ADP-Ribose Antibody - LS-C191166 from LifeSpan Bioscience

Prices $680.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PAR / Poly ADP-Ribose Antibody (clone 10H) - LS-C345084 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10H

Anti-PAR / Poly ADP-Ribose Antibody (clone 10H) IHC-plus™ - LS-B4771 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 10H
Anti-Poly ADP-Ribose antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4771 concentration 5 ug/ml.

JTB Antibody - NBP1-81746 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: JTB Antibody [NBP1-81746] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

PAR/pADPr Antibody [Unconjugated] - 4336-APC-050 from Novus Biologicals

Prices $401.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of Wehi cellsuntreated (H) and treated (T) with 25 μM Etoposidefor 4 hours at 37 °C. Cells were lysed in Tris-GlycineSDS sample buffer at the concentration of 1 x 107cells/ml, and 10 μl of clarified lysate were loadedper well of 4-20% Tris-Glycine gel. Proteins weretransferred onto an Immobilon FL membrane andribosylated proteins were detected using Trevigen'spolyclonal anti-PAR antibody (cat# 4336-APC-050)followed by an IR680-conjugated secondary antibody(Licor). The membrane was scanned using anOdyssey Infrared Imaging System (Licor).

JTB Antibody - H00010899-B02 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: JTB Antibody [H00010899-B02] - analysis of JTB expression in transfected 293T cell line by JTB MaxPab polyclonal antibody (B02). Lane 1: JTB transfected lysate (16.40 KDa). Lane 2: Non-transfected lysate.

JTB Antibody (4E7) - H00010899-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E7
Sandwich ELISA: JTB Antibody (4E7) [H00010899-M02] - Detection limit for recombinant GST tagged JTB is approximately 1ng/ml as a capture antibody.

JTB Antibody - H00010899-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: JTB Antibody [H00010899-A01] - JTB polyclonal antibody (A01), Lot # NBI0061124QCS1 Western Blot analysis of JTB expression in IMR-32 ( Cat # L008V1 ).

JTB Antibody - H00010899-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: JTB Antibody [H00010899-B01P] - Analysis of JTB expression in transfected 293T cell line by JTB polyclonal antibody. Lane 1: JTB transfected lysate(16.17 KDa). Lane 2: Non-transfected lysate.

Anti-JTB antibody produced in mouse - SAB1408799 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-JTB: <B>Cat. No. SAB1408799</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~16.2 kDa using JTB transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-JTB antibody produced in rabbit - HPA006514 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-JTB: <B>Cat. No. HPA006514</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human stomach tissue showing cytoplasmic positivity in glandular cells.

JTB-Antibody-monoclonal-M02 - AT2586a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E8
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (41.8 KDa) .

JTB antibody [N1C3] - GTX102123 from GeneTex

Host Rabbit
Clonality Polyclonal

PAR/pADPr Antibody - 4336-APC-050 from R&D Systems

Prices $401.00
Sizes 50 µl
Host Rabbit
Detection of PAR/pADPr by Western Blot. Western blot analysis of Wehi cellsuntreated (H) and treated (T) with 25 μM Etoposidefor 4 hours at 37 °C. Cells were lysed in Tris-GlycineSDS sample buffer at the concentration of 1 x 10 7 cells/ml, and 10 μl of clarified lysate were loadedper well of 4-20% Tris-Glycine gel. Proteins weretransferred onto an Immobilon FL membrane andribosylated proteins were detected using Trevigen'spolyclonal anti-PAR antibody (cat# 4336-APC-050)followed by an IR680-conjugated secondary antibody(Licor). The membrane was scanned using anOdyssey Infrared Imaging System (Licor).

JTB Antibody (OAAF06550) - OAAF06550 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

JTB antibody - orb78108 from Biorbyt

Prices $425.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of fetal brain and fetal lung lysate using JTB antibody
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