JTB

Gene Symbol	JTB
Entrez Gene	10899
Alt Symbol	HJTB, HSPC222, PAR, hJT
Species	Human
Gene Type	protein-coding
Description	jumping translocation breakpoint
Other Description	jumping translocation breakpoint protein|prostate androgen-regulated protein|protein JTB
Swissprots	Q6IB19 O95442 O76095 Q9P0Q4
Accessions	BAA33735 BAA33736 EAW53242 O76095 AB016488 BAA33731 AF115850 AAD09822 AF131797 AAD20045 AF151056 AAF36142 AK312106 BAG35042 BC000499 AAH00499 BC000996 AAH00996 BC001363 AAH01363 BC001667 AAH01667 BC004239 AAH04239 BC019277 AAH19277 BM907938 BT007285 AAP35949 BU527541 CR456985 CAG33266 NM_006694 NP_006685
Function	Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
Tissue Specificity	Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. {ECO:0000269|PubMed:10321732, ECO:0000269|PubMed:10762645, ECO:0000269|PubMed:17369841, ECO:0000269|PubMed:21225229}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JTB 293T Cell Transient Overexpression Lysate(Denatured) - H00010899-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

JTB 293T Cell Transient Overexpression Lysate(Denatured) - H00010899-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

JTB overexpression lysate - LY402003 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

JTB 293 Cell Lysate - 401781 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

JTB Overexpression Lysate (Denatured) - H00010899-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

JTB Overexpression Lysate (Denatured) - H00010899-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

JTB Overexpression Lysate (Native) - NBL1-12112 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

JTB Over-expression Lysate Product - GWB-655583 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human Jumping Translocation Breakpoint / JTB HEK293 Cell Lysate (WB positive control) - 13447-H05HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Jumping Translocation Breakpoint Human Cells Transfected Lysate (positive control) (denatured) - orb174626 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human JTB Knockdown Stable Cell Line - CSC-DC007877 from Creative biogene Category Cell Line Species Human

Search more