JTB

Gene Symbol	JTB
Entrez Gene	10899
Alt Symbol	HJTB, HSPC222, PAR, hJT
Species	Human
Gene Type	protein-coding
Description	jumping translocation breakpoint
Other Description	jumping translocation breakpoint protein|prostate androgen-regulated protein|protein JTB
Swissprots	Q6IB19 O95442 O76095 Q9P0Q4
Accessions	BAA33735 BAA33736 EAW53242 O76095 AB016488 BAA33731 AF115850 AAD09822 AF131797 AAD20045 AF151056 AAF36142 AK312106 BAG35042 BC000499 AAH00499 BC000996 AAH00996 BC001363 AAH01363 BC001667 AAH01667 BC004239 AAH04239 BC019277 AAH19277 BM907938 BT007285 AAP35949 BU527541 CR456985 CAG33266 NM_006694 NP_006685
Function	Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
Tissue Specificity	Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. {ECO:0000269|PubMed:10321732, ECO:0000269|PubMed:10762645, ECO:0000269|PubMed:17369841, ECO:0000269|PubMed:21225229}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human JTB full length protein - ab132615 from Abcam Category Protein Source Wheat germ Species Human

Human JTB protein fragment - ab183230 from Abcam Category Protein Source E. coli Species Human

JTB protein (His-DHFR tag) - ab127596 from Abcam Category Protein Source E. coli Species Human

JTB Recombinant Protein - H00010899-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Human JTB protein - orb139237 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Human Cells Species Human

Borrelia burgdorferi ospC protein (His tag) - 80-1353 from Fitzgerald Category Protein Prices $195.00, $975.00 Sizes 100 µg, 1 mg Source E.coli

JTB protein (His tag) - 80R-3915 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

JTB (31-105, His-tag) - AR51602PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

JTB (31-105, His-tag) - AR51602PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

JTB - H00010899-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

JTB - H00010899-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

JTB fusion protein - ag0744 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

JTB fusion protein - ag13164 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human JTB, Fc tagged - JTB-377H from Creative Biomart Category Protein Source Human Cells Species Human

Human Jumping Translocation Breakpoint / JTB Protein (Fc Tag) - 13447-H05H-100 from Sino Biological Category Protein Prices $348.00, $348.00 Sizes 20 µg, 100 µg Source Human Cells Species Human

Recombinant Human Protein JTB(JTB) - CSB-YP011970HU CSB-EP011970HU CSB-BP011970HU CSB-MP011970HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

JTB, 31-105aa, Human, His tag, E.coli - ATGP2782 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 4 µg, 20 µg, 100 µg Species Human

Jumping Translocation Breakpoint Protein (Recombinant) - abx262811 from Abbexa Category Protein

Recombinant Human Jumping Translocation Breakpoint / JTB Protein (Fc tag) - PKSH030629 from Elabscience Category Protein Source Human Cell Species Human

Recombinant Brugia malayi (Filarial nematode worm) Brugia malayi (Filarial nematode worm) - CSB-EP011970BMV from Cusabio Category Protein

JTB Recombinant Protein Antigen - NBP1-81746PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

JTB Peptide, Human - M34GP07877H from Creative Peptides Category Peptide Source Synthetic. Species Human

JTB Recombinant Protein (OPCA03570) - OPCA03570 from Aviva Systems Biology Category Protein Prices $365.00 Sizes 50 µg Source Brugia malayi

Recombinant Human JTB Protein - NBP2-51795 from Novus Biologicals Category Protein Prices $259.00, $759.00 Sizes 20 µg, 100 µg Source E.coli Species Human

JTB - PAT-82781-1 from Nordic BioSite Category Protein Species Human

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