DPP4

Gene Symbol	DPP4
Entrez Gene	1803
Alt Symbol	ADABP, ADCP2, CD26, DPPIV, TP103
Species	Human
Gene Type	protein-coding
Description	dipeptidyl-peptidase 4
Other Description	ADCP-2|DPP IV|T-cell activation antigen CD26|adenosine deaminase complexing protein 2|dipeptidyl peptidase 4|dipeptidyl peptidase IV|dipeptidylpeptidase 4|dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
Swissprots	Q53TN1 P27487
Accessions	AAB35614 AAB60646 AAX93179 CAF33874 CBX53886 EAX11361 EAX11362 P27487 AB451339 BAG70153 AB451488 BAG70302 AK314798 AY429531 AY429532 AY429533 BC013329 AAH13329 BC065265 AAH65265 M74777 AAA51943 M80536 AAA52308 X60708 CAA43118 XM_005246371 XP_005246428 NM_001935 NP_001926
Function	Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth fact
Subcellular Location	Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid.
Tissue Specificity	Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. {ECO:0000269|PubMed:1677636, ECO:0000269|PubMed:18708048}.
Top Pathways	Protein digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD26 Human ELISA Kit - ab119513 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity 7.3 ng/ml Range 15.6 ng/ml - 500 ng/ml

Dipeptidyl peptidase IV (DPP4) Inhibitor Screening Assay Kit - ab133081 from Abcam Category Cellular Assay Prices $448.00 Sizes 96 tests

Human DPP4 / CD26 ELISA Kit (Sandwich ELISA) - LS-F4215 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.261 ng/ml Range 32.77-3200 pg/ml

Rat DPP4 / CD26 ELISA Kit (Sandwich ELISA) - LS-F4216 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.256 ng/ml Range 32.77-3200 pg/ml

Mouse DPP4 / CD26 ELISA Kit (Sandwich ELISA) - LS-F4217 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 4.8 pg/ml Range 32.77-3200 pg/ml

Human DPP4 / CD26 ELISA Kit (Sandwich ELISA) - LS-F2630 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 32.77-3200 pg/ml

Mouse DPP4 / CD26 ELISA Kit (Sandwich ELISA) - LS-F2631 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 32.77-3200 pg/ml

Human DPP4 / CD26 ELISA Kit (Sandwich ELISA) - LS-F50 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 32.77 pg/ml Range 32.77-3200 pg/ml

Human DPP4 / CD26 ELISA Kit (Sandwich ELISA) - LS-F1022 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 32.77-3200 pg/ml

Mouse DPP4 / CD26 ELISA Kit (Sandwich ELISA) - LS-F11321 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 32.77-3200 pg/ml

Human DPP4 / CD26 ELISA Kit (Sandwich ELISA) - LS-F11320 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 78 Range 32.77-3200 pg/ml

DPPIV/CD26 Assay/Inhibitor Screening Assay Kit - KA1311 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

Human DPPIV / CD26  ELISA Kit - RAB0147 from Sigma-Aldrich Category ELISA Kit Prices $438.50 Sizes 1 kt

CD26/ DPP4 BioAssay™ ELISA Kit, Human - 143765 from USBiological Life Science Category ELISA Kit Sensitivity < 10 pg/ml Range 312pg/ml-20,000pg/ml

CD26/DPP4 BioAssay™ ELISA Kit, Mouse - 143766 from USBiological Life Science Category ELISA Kit Sensitivity < 10 pg/ml Range 62.5pg/ml-4000pg/ml

Human DPPIV/CD26 DuoSet ELISA - DY1180 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Mouse DPPIV/CD26 DuoSet ELISA - DY954 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

DPPIV ELISA Kit (Human) : 96 Wells (OKAG00222) - OKAG00222 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 32 pg/mL Range 32-2,000 pg/mL

Human CD26 ELISA Kit - orb219300 from Biorbyt Category ELISA Kit Prices $706.00 Sizes 96 test Sensitivity 10 pg/ml Range 312 pg/ml-20000 pg/ml

Human CD26 ELISA Kit - abx056086 from Abbexa Category ELISA Kit

Human DPP4 ELISA Kit - abx151345 from Abbexa Category ELISA Kit Sensitivity 14.1 pg/ml Range 31.25 pg/ml - 2000 pg/ml

CD26/ DPP4, Human, ELISA Kit - PB-0696 from ARP American Research Products Category ELISA Kit Prices $418.00 Sizes 96 t Sensitivity < 10 pg/ml Range 312pg/ml-20,000pg/ml

Dipeptidyl peptidase 4, DPP4, Human, ELISA Kit - E0884h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 78-5000 pg/mL

Dipeptidyl peptldase IV, DPPIV, Human, ELISA Kit - CSB-E08518h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Dipeptidyl Peptidase IV, DPP4, Human, ELISA Kit - E-EL-H0058 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

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