DPP4

Gene Symbol	DPP4
Entrez Gene	1803
Alt Symbol	ADABP, ADCP2, CD26, DPPIV, TP103
Species	Human
Gene Type	protein-coding
Description	dipeptidyl-peptidase 4
Other Description	ADCP-2\|DPP IV\|T-cell activation antigen CD26\|adenosine deaminase complexing protein 2\|dipeptidyl peptidase 4\|dipeptidyl peptidase IV\|dipeptidylpeptidase 4\|dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
Swissprots	Q53TN1 P27487
Accessions	AAB35614 AAB60646 AAX93179 CAF33874 CBX53886 EAX11361 EAX11362 P27487 AB451339 BAG70153 AB451488 BAG70302 AK314798 AY429531 AY429532 AY429533 BC013329 AAH13329 BC065265 AAH65265 M74777 AAA51943 M80536 AAA52308 X60708 CAA43118 XM_005246371 XP_005246428 NM_001935 NP_001926
Function	Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth fact
Subcellular Location	Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid.
Tissue Specificity	Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. {ECO:0000269\|PubMed:1677636, ECO:0000269\|PubMed:18708048}.
Top Pathways	Protein digestion and absorption

CD26 (H-270) - sc-9153 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CD26 (H-270): sc-9153. Western blot analysis of CD26 expression in CCRF-CEM (A), GA-10 (B) and AML-193 (C) whole cell lysates.

CD26 (BA5) - sc-19607 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CD26 (BA5) PE: sc-19607 PE. FCM analysis of human peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal mouse IgG<sub>2a</sub>: sc-2867.

CD26 (202.36) - sc-7633 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CD26 (202.36) PE: sc-7633 PE. FCM analysis of human peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal mouse IgG<sub>2b</sub>: sc-2868.

CD26 (S-15) - sc-323729 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CD26 (S-15): sc-323729. Western blot analysis of CD26 expression in rat kidney tissue extract.

Anti-CD26 antibody - ab28340 from Abcam

Prices	$384.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CD26 antibody (ab28340) at 1/1000 dilutionLane 1 : DPP-4 at 0.08 µgLane 2 : DPP-4 at 0.04 µgLane 3 : DPP-4 at 0.02 µgLane 4 : DPP-4 at 0.01 µg

Anti-CD26 antibody - ab28339 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CD26 antibody (ab28339) at 1/1000 dilutionLane 1 : Recombinant Human DPP-4 at 0.08 µgLane 2 : Recombinant Human DPP-4 at 0.04 µgLane 3 : Recombinant Human DPP-4 at 0.02 µgLane 4 : Recombinant Human DPP-4 at 0.01 µg

Anti-CD26 antibody - ab86806 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CD26 antibody (ab86806) at 1 µg/mlLane 1 : Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276)Lane 2 : Ovary (Human) Tissue Lysate - adult normal tissue (ab30222)Lane 3 : Breast (Human) Tissue Lysate - normal tissue (ab30090)Lane 4 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CD26 antibody [11D7] - ab114033 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	11D7

All lanes : Anti-CD26 antibody [11D7] (ab114033) at 1/500 dilutionLane 1 : HEK293T cells were transfected with the pCMV6-ENTRY control cDNA for 48 hrs and lysedLane 2 : HEK293T cells were transfected with the pCMV6-ENTRY DPP4 cDNA for 48 hrs and lysedLysates/proteins at 5 µg per lane.

Anti-CD26 antibody [134-2C2] (FITC) - ab82433 from Abcam

Prices	$186.00
Sizes	50 tests
Host	Mouse
Clonality	Monoclonal
Clone	134-2C2

Anti-CD26 antibody [134-2C2] (Phycoerythrin) - ab82437 from Abcam

Prices	$372.00
Sizes	50 tests
Host	Mouse
Clonality	Monoclonal
Clone	134-2C2

Anti-CD26 antibody [202-36] - ab3154 from Abcam

Prices	$379.00
Sizes	500 µl
Host	Mouse
Clonality	Monoclonal
Clone	202-36

All lanes : Anti-CD26 antibody [202-36] (ab3154) at 5 µg/mlLane 1 : U-87 MG (Human glioblastoma astrocytoma) Whole Cell Lysate Lane 2 : Ramos (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Mouse IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-CD26 antibody [202-36] - ab76517 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	202-36

Anti-CD26 antibody [236.3] - ab119346 from Abcam

Prices	$385.00
Sizes	500 µg
Host	Mouse
Clonality	Monoclonal
Clone	236.3

Flow cytometry analysis of CD26 in PC12 cells (green) compared to an isotype control (blue). Cells were harvested, adjusted to a concentration of 1-5x10^6 cells/ml, fixed with 2% paraformaldehyde and washed with PBS. Cells were blocked with a 2% solution of BSA-PBS for 30 min at room temperature and incubated with a CD26 monoclonal antibody (ab119346) at a dilution of 2 ug/test for 60 min at room temperature. Cells were then incubated for 40 min at room temperature in the dark using a Dylight 488-conjugated secondary antibody and re-suspended in PBS for FACS analysis.

Anti-CD26 antibody [BA5b] - ab134409 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	BA5b

Anti-CD26 antibody [BA5b], prediluted (Allophycocyanin) - ab134412 from Abcam

Prices	$370.00
Sizes	50 tests
Host	Mouse
Clonality	Monoclonal
Clone	BA5b

Anti-CD26 antibody [BA5b], prediluted (FITC) - ab134410 from Abcam

Prices	$370.00
Sizes	50 tests
Host	Mouse
Clonality	Monoclonal
Clone	BA5b

Anti-CD26 antibody [BA5b], prediluted (Phycoerythrin) - ab134411 from Abcam

Prices	$370.00
Sizes	50 tests
Host	Mouse
Clonality	Monoclonal
Clone	BA5b

Anti-CD26 antibody [EPR5883(2)] - ab129060 from Abcam

Prices	$381.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR5883(2)

All lanes : Anti-CD26 antibody [EPR5883(2)] (ab129060) at 1/20000 dilution (purified)Lane 1 : HUVEC cell lysateLane 2 : PC-3 cell lysateLane 3 : U87-MG cell lysateLane 4 : Ramos cell lysateLysates/proteins at 20 µg per lane.SecondaryPeroxidase conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-CD26 antibody [MM0249- 1G24] - ab89398 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Rat
Clonality	Monoclonal
Clone	MM0249- 1G24

Anti-CD26 antibody [TP1/19] - ab91166 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	TP1/19

Anti-CD26 antibody [TP1/19] (Allophycocyanin) - ab91171 from Abcam

Prices	$188.00
Sizes	50 tests
Host	Mouse
Clonality	Monoclonal
Clone	TP1/19

ab91171 at 20 µl per 106 cells detecting CD26 in normal Human peripheral blood (EDTA-anticoagulated) by flow cytometry.

Anti-CD26 antibody [TP1/19] (CF405M) - ab119480 from Abcam

Prices	$376.00
Sizes	50 tests
Host	Mouse
Clonality	Monoclonal
Clone	TP1/19

ab119480, at 5 µl/106 cells, staining CD26 in normal Human peripheral blood cells by Flow Cytometry. Cells in the leukocyte gate were used for the analysis.

Anti-CD26 antibody [TP1/19] (FITC) - ab91168 from Abcam

Prices	$376.00
Sizes	50 tests
Host	Mouse
Clonality	Monoclonal
Clone	TP1/19

ab91168 detecting CD26 in normal Human blood by Flow Cytometry.

Anti-CD26 antibody [TP1/19] (Phycoerythrin) - ab91170 from Abcam

Prices	$376.00
Sizes	50 tests
Host	Mouse
Clonality	Monoclonal
Clone	TP1/19

ab91170 at 20 µl per 106 cells detecting CD26 in normal Human peripheral blood (EDTA-anticoagulated) by flow cytometry.

Anti-CD26 antibody - Carboxyterminal end - ab28341 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CD26 antibody - Carboxyterminal end (ab28341) at 1/1000 dilutionLane 1 : Recombinant human DPP4/CD26 at 0.08 µgLane 2 : Recombinant human DPP4/CD26 at 0.04 µgLane 3 : Recombinant human DPP4/CD26 at 0.02 µgLane 4 : Recombinant human DPP4/CD26 at 0.01 µg

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