DPP4

Gene Symbol	DPP4
Entrez Gene	1803
Alt Symbol	ADABP, ADCP2, CD26, DPPIV, TP103
Species	Human
Gene Type	protein-coding
Description	dipeptidyl-peptidase 4
Other Description	ADCP-2|DPP IV|T-cell activation antigen CD26|adenosine deaminase complexing protein 2|dipeptidyl peptidase 4|dipeptidyl peptidase IV|dipeptidylpeptidase 4|dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
Swissprots	Q53TN1 P27487
Accessions	AAB35614 AAB60646 AAX93179 CAF33874 CBX53886 EAX11361 EAX11362 P27487 AB451339 BAG70153 AB451488 BAG70302 AK314798 AY429531 AY429532 AY429533 BC013329 AAH13329 BC065265 AAH65265 M74777 AAA51943 M80536 AAA52308 X60708 CAA43118 XM_005246371 XP_005246428 NM_001935 NP_001926
Function	Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth fact
Subcellular Location	Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid.
Tissue Specificity	Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. {ECO:0000269|PubMed:1677636, ECO:0000269|PubMed:18708048}.
Top Pathways	Protein digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CD26 full length protein - ab79138 from Abcam Category Protein Prices $308.00, $1,279.00 Sizes 100 µg, 500 µg Source Baculovirus infected High-5 cells Species Human

Active human CD26 full length protein - ab134443 from Abcam Category Protein Prices $873.00 Sizes 10 µg Source Native Species Human

Active human CD26 full length protein - ab129472 from Abcam Category Protein Prices $961.00 Sizes 50 µg Source High-5 insect cells Species Human

Active human CD26 protein fragment - ab155641 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human CD26 protein fragment - ab155725 from Abcam Category Protein Prices $588.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human CD26 protein fragment - ab79659 from Abcam Category Protein Prices $492.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active pig CD26 full length protein - ab134449 from Abcam Category Protein Source Native Species Pig

CD26 peptide - ab41393 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

CD26 peptide - ab41394 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

CD26 peptide - ab41396 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

CD26 peptide - ab188121 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CD26 full length protein - ab158308 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human CD26 peptide - ab95406 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human CD26 protein fragment - ab155730 from Abcam Category Protein Prices $456.00 Sizes 50 µg Source HEK 293 cells Species Human

Human CD26 protein fragment - ab158309 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

DPP4 / CD26 Antibody Blocking Peptide - LS-E5373 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DPP4 / CD26 Antibody Blocking Peptide - LS-E29541 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DPP4 / CD26 Antibody Blocking Peptide - LS-E29542 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DPP4 / CD26 Antibody Blocking Peptide - LS-E29540 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DPP4 / CD26 Antibody Blocking Peptide - LS-E23094 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DPP4 / CD26 Antibody Blocking Peptide - LS-E26365 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DPP4 / CD26 Antibody Blocking Peptide - LS-E29323 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DPP4 / CD26 Antibody Blocking Peptide - LS-E29325 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DPP4 / CD26 Antibody Blocking Peptide - LS-E29326 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DPPIV/CD26 Recombinant Protein - H00001803-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

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