DPP4

Gene Symbol	DPP4
Entrez Gene	1803
Alt Symbol	ADABP, ADCP2, CD26, DPPIV, TP103
Species	Human
Gene Type	protein-coding
Description	dipeptidyl-peptidase 4
Other Description	ADCP-2|DPP IV|T-cell activation antigen CD26|adenosine deaminase complexing protein 2|dipeptidyl peptidase 4|dipeptidyl peptidase IV|dipeptidylpeptidase 4|dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
Swissprots	Q53TN1 P27487
Accessions	AAB35614 AAB60646 AAX93179 CAF33874 CBX53886 EAX11361 EAX11362 P27487 AB451339 BAG70153 AB451488 BAG70302 AK314798 AY429531 AY429532 AY429533 BC013329 AAH13329 BC065265 AAH65265 M74777 AAA51943 M80536 AAA52308 X60708 CAA43118 XM_005246371 XP_005246428 NM_001935 NP_001926
Function	Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth fact
Subcellular Location	Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid.
Tissue Specificity	Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. {ECO:0000269|PubMed:1677636, ECO:0000269|PubMed:18708048}.
Top Pathways	Protein digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DPP4 293T Cell Transient Overexpression Lysate(Denatured) - H00001803-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

DPP4 overexpression lysate - LY419637 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

DPP4 293 Cell Lysate - 409192 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

DPPIV/CD26 Overexpression Lysate (Denatured) - H00001803-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

DPPIV/CD26 Overexpression Lysate (Native) - NBL1-09997 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DPP4 Over-expression Lysate Product - GWB-263B60 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Cynomolgus DPP4 / CD26 (ECD) HEK293 Cell Lysate (WB positive control) - 90180-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human DPP4 / CD26 HEK293 Cell Lysate (WB positive control) - 10688-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Cynomolgus DPP4 / DPPIV / CD26 HEK293 Cell Lysate (WB positive control) - 90180-CNCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human CD26 Human Cells Transfected Lysate (positive control) (denatured) - orb232840 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human DPP4 Knockdown Stable Cell Line - CSC-DC004516 from Creative biogene Category Cell Line Species Human

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