| Gene Symbol |
MAP3K12
|
| Entrez Gene |
7786
|
| Alt Symbol |
DLK, MEKK12, MUK, ZPK, ZPKP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase 12
|
| Other Description |
MAPK-upstream kinase|dual leucine zipper bearing kinase|dual leucine zipper kinase DLK|leucine zipper protein kinase|mixed lineage kinase|protein kinase MUK
|
| Swissprots |
Q8WY25 Q86VQ5 B3KSS9 Q12852 G3V1Y2
|
| Accessions |
AAL67158 EAW96712 EAW96713 EAW96714 EAW96715 EAW96716 Q12852 AB209453 BAD92690 AK094195 BAG52841 AK314530 BC037585 BC050050 AAH50050 U07358 AAA67343 XM_005269138 XP_005269195 XM_005269140 XP_005269197 XM_006719588 XP_006719651 XM_006719589 XP_006719652 XM_011538725 XP_011537027 XM_011538726 XP_011537028 NM_001193511 NP_001180440 NM_006301 NP_006292
|
| Function |
May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain and kidney.
|
| Top Pathways |
MAPK signaling pathway
|