MAP3K12

Gene Symbol MAP3K12
Entrez Gene 7786
Alt Symbol DLK, MEKK12, MUK, ZPK, ZPKP1
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 12
Other Description MAPK-upstream kinase|dual leucine zipper bearing kinase|dual leucine zipper kinase DLK|leucine zipper protein kinase|mixed lineage kinase|protein kinase MUK
Swissprots Q8WY25 Q86VQ5 B3KSS9 Q12852 G3V1Y2
Accessions AAL67158 EAW96712 EAW96713 EAW96714 EAW96715 EAW96716 Q12852 AB209453 BAD92690 AK094195 BAG52841 AK314530 BC037585 BC050050 AAH50050 U07358 AAA67343 XM_005269138 XP_005269195 XM_005269140 XP_005269197 XM_006719588 XP_006719651 XM_006719589 XP_006719652 XM_011538725 XP_011537027 XM_011538726 XP_011537028 NM_001193511 NP_001180440 NM_006301 NP_006292
Function May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Highly expressed in brain and kidney.
Top Pathways MAPK signaling pathway

ZPK (H-130) - sc-366564 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ZPK (N-19) - sc-8125 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MAP3K12 antibody - ab37996 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MAP3K12 antibody (ab37996) at 1/1000 dilutionLane 1 : HL-60 cell lysateLane 2 : SH-SY5Y cell lysateLysates/proteins at 35 µg per lane.SecondaryHRP-conjugated goat anti-rabbit IgG (H+L) at 1/10000 dilution

Anti-MAP3K12 antibody - ab175860 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-MAP3K12 antibody (ab175860) at 1/1000 dilution + HeLa cell lysate at 35 µg

Anti-MAP3K12 Antibody (C-Terminus, FITC) - LS-C225795 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K12 Antibody (C-Terminus, Biotin) - LS-C225793 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K12 Antibody (C-Terminus, AP) - LS-C225788 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K12 Antibody (C-Terminus, APC) - LS-C225794 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K12 Antibody (aa828-859) - LS-C158096 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
MAP3K12 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The MAP3K12 antibody detected the MAP3K12 protein (arrow).

Anti-MAP3K12 Antibody (C-Terminus, Azide-free, HRP) - LS-C225796 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K12 Antibody (C-Terminus, PE) - LS-C225797 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K12 Antibody (C-Terminus, Azide-free) - LS-C330526 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K12 Antibody (aa828-859) - LS-C158095 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
MAP3K12 Antibody western blot of T47D cell line lysates (35 ug/lane). The MAP3K12 antibody detected the MAP3K12 protein (arrow).

Anti-MAP3K12 Antibody (aa828-859) - LS-C100740 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

MAP3K12 Antibody - NBP1-85013 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: MAP3K12 Antibody [NBP1-85013] - Staining of human gallbladder shows strong cytoplasmic positivity in glandular cells.

MAP3K12 Antibody - NBP1-46063 from Novus Biologicals

Prices $449.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: MAP3K12 Antibody [NBP1-46063] - Analysis using the FITC conjugate of NBP1-46063. Detection of MAP3K12 (MAP3K12-AP) antibody (1:500) in diluObuffer with PC-MAP3K12 samples. Ln 1: Mock transfected cells; Ln 2: MAP3K12 transfectred cells.

MAP3K12 Antibody [FITC] - NBP1-62734 from Novus Biologicals

Prices $459.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: MAP3K12 Antibody [FITC] [NBP1-62734] - WB of MAP3K12 (MAP3K12-AP) antibody (1:500) in diluObuffer with PC-MAP3K12 samples.  Ln 1:  Mock transfected cells; Ln 2:  MAP3K12 transfectred ccells.

ANTI-MAP3K12 antibody produced in mouse - SAB1306766 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Mouse
Clonality Polyclonal

Anti-MAP3K12 antibody produced in rabbit - HPA039936 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MAP3K12: <B>Cat. No. HPA039936</B>: Immunohistochemical staining of human stomach, upper shows strong cytoplasmic positivity in glandular cells.

ANTI-ZPK(C-TERMINAL) antibody produced in rabbit - SAB1307114 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal

Anti-ZPK (center) antibody produced in rabbit - SAB1300426 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

ANTI-MAP3K12 antibody produced in mouse - SAB1306765 from Sigma-Aldrich

Prices $326.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Monoclonal Anti-MAP3K12 (Ascites): <B>Cat. No. SAB1306765</B>: MAP3K12 Antibody western blot analysis in Mouse brain tissue lysates (35 μg/lane)

MAP3K12 Antibody (Ascites) (OAAB07035) - OAAB07035 from Aviva Systems Biology

Prices $320.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 473CT23.12.5

MAP3K12 Antibody (OAAB07036) - OAAB07036 from Aviva Systems Biology

Prices $320.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 473CT23.12.5

MAP3K12-Antibody - AM2057b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Mouse
Clonality Monoclonal
Clone 473CT23.12.5
MAP3K12 Antibody (Cat. #AM2057b) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the MAP3K12 antibody detected the MAP3K12 protein (arrow).
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