Gene Symbol | MAP3K12 |
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Entrez Gene | 7786 |
Alt Symbol | DLK, MEKK12, MUK, ZPK, ZPKP1 |
Species | Human |
Gene Type | protein-coding |
Description | mitogen-activated protein kinase kinase kinase 12 |
Other Description | MAPK-upstream kinase|dual leucine zipper bearing kinase|dual leucine zipper kinase DLK|leucine zipper protein kinase|mixed lineage kinase|protein kinase MUK |
Swissprots | Q8WY25 Q86VQ5 B3KSS9 Q12852 G3V1Y2 |
Accessions | AAL67158 EAW96712 EAW96713 EAW96714 EAW96715 EAW96716 Q12852 AB209453 BAD92690 AK094195 BAG52841 AK314530 BC037585 BC050050 AAH50050 U07358 AAA67343 XM_005269138 XP_005269195 XM_005269140 XP_005269197 XM_006719588 XP_006719651 XM_006719589 XP_006719652 XM_011538725 XP_011537027 XM_011538726 XP_011537028 NM_001193511 NP_001180440 NM_006301 NP_006292 |
Function | May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro. |
Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
Tissue Specificity | Highly expressed in brain and kidney. |
Top Pathways | MAPK signaling pathway |
ZPK (H-130) - sc-366564 from Santa Cruz Biotechnology
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ZPK (N-19) - sc-8125 from Santa Cruz Biotechnology
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Anti-MAP3K12 antibody - ab37996 from Abcam
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Anti-MAP3K12 antibody - ab175860 from Abcam
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Anti-MAP3K12 Antibody (C-Terminus, FITC) - LS-C225795 from LifeSpan Bioscience
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Anti-MAP3K12 Antibody (C-Terminus, Biotin) - LS-C225793 from LifeSpan Bioscience
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Anti-MAP3K12 Antibody (C-Terminus, AP) - LS-C225788 from LifeSpan Bioscience
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Anti-MAP3K12 Antibody (C-Terminus, APC) - LS-C225794 from LifeSpan Bioscience
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Anti-MAP3K12 Antibody (aa828-859) - LS-C158096 from LifeSpan Bioscience
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Anti-MAP3K12 Antibody (C-Terminus, Azide-free, HRP) - LS-C225796 from LifeSpan Bioscience
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Anti-MAP3K12 Antibody (C-Terminus, PE) - LS-C225797 from LifeSpan Bioscience
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Anti-MAP3K12 Antibody (C-Terminus, Azide-free) - LS-C330526 from LifeSpan Bioscience
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Anti-MAP3K12 Antibody (aa828-859) - LS-C158095 from LifeSpan Bioscience
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Anti-MAP3K12 Antibody (aa828-859) - LS-C100740 from LifeSpan Bioscience
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MAP3K12 Antibody - NBP1-85013 from Novus Biologicals
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MAP3K12 Antibody - NBP1-46063 from Novus Biologicals
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MAP3K12 Antibody [FITC] - NBP1-62734 from Novus Biologicals
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ANTI-MAP3K12 antibody produced in mouse - SAB1306766 from Sigma-Aldrich
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Anti-MAP3K12 antibody produced in rabbit - HPA039936 from Sigma-Aldrich
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ANTI-ZPK(C-TERMINAL) antibody produced in rabbit - SAB1307114 from Sigma-Aldrich
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Anti-ZPK (center) antibody produced in rabbit - SAB1300426 from Sigma-Aldrich
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ANTI-MAP3K12 antibody produced in mouse - SAB1306765 from Sigma-Aldrich
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MAP3K12 Antibody (Ascites) (OAAB07035) - OAAB07035 from Aviva Systems Biology
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MAP3K12 Antibody (OAAB07036) - OAAB07036 from Aviva Systems Biology
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MAP3K12-Antibody - AM2057b from Abgent, a WuXi AppTec company
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