| Gene Symbol |
MYH9
|
| Entrez Gene |
4627
|
| Alt Symbol |
BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myosin, heavy chain 9, non-muscle
|
| Other Description |
cellular myosin heavy chain, type A|myosin-9|non-muscle myosin heavy chain A|non-muscle myosin heavy chain IIa|non-muscle myosin heavy polypeptide 9|nonmuscle myosin heavy chain II-A
|
| Swissprots |
P35579 Q86T83 Q60FE2 A8K6E4 O60805
|
| Accessions |
ABC25483 CBX47535 EAW60096 EAW60097 EAW60098 P35579 AA420536 AB191263 BAD52439 AB290175 BAG06729 AK025219 AK025393 AK131080 BAC85130 AK291609 BAF84298 AK304840 BAG65583 AL832639 CAD89954 BC011915 BC049849 AAH49849 BC090921 AAH90921 BC111387 BC150169 AAI50170 BC150170 AAI50171 CD614930 CR456526 CAG30412 CU013126 CAK54557 CU013414 CAK54856 D11393 BAA01989 DC296130 L29141 AAA20904 M31013 AAA36349 M69180 AAA61765 M81105 AAA59888 XM_011530197 XP_011528499 NM_002473 NP_002464
|
| Function |
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10. {ECO:0000269|PubMed:20052411}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells. {ECO:0000269|PubMed:20052411}.
|
| Tissue Specificity |
In the kidney, expressed in the glomeruli. Also expressed in leukocytes. {ECO:0000269|PubMed:11752022, ECO:0000269|PubMed:1912569}.
|
| Top Pathways |
Tight junction, Salmonella infection, Regulation of actin cytoskeleton
|