KISS1R

Gene Symbol KISS1R
Entrez Gene 84634
Alt Symbol AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R
Species Human
Gene Type protein-coding
Description KISS1 receptor
Other Description G protein-coupled receptor 54|G-protein coupled receptor OT7T175|hypogonadotropin-1|kiSS-1 receptor|kisspeptins receptor|metastin receptor
Swissprots B2RTV1 A5D8U2 Q96QG0 Q969F8
Accessions CAH60299 CAH68808 EAW69583 Q969F8 AA887801 AB051065 BAB55446 AF343725 AAK83235 AJ309020 CAC40817 AY029541 AAK33126 AY253981 AAP82929 AY253982 AAP82930 BC140825 AAI40826 BC141812 AAI41813 CA432866 EU883577 ACG60651 NM_032551 NP_115940
Function Receptor for metastin (kisspeptin-54 or kp-54), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine- tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. {ECO:0000269|PubMed:15020672}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism. {ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:11387329, ECO:0000269|PubMed:11414709, ECO:0000269|PubMed:11457843, ECO:0000269|PubMed:12414911, ECO:0000269|PubMed:15020672}.
Top Pathways Neuroactive ligand-receptor interaction

KISS1R (D9D7C) Rabbit mAb - 13776 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9D7C
Western blot analysis of extracts from various tissues and cell lines using KISS1R (D9D7C) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

GPR54 (H-202) - sc-134499 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

GPR54 (N-14) - sc-48219 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GPR54 (N-20) - sc-48220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GPR54 (N-20): sc-48220. Western blot analysis of GPR54 expression in HeLa (A), MCF7 (B), MIA PaCa-2 (C), PANC-1 (D) and MDA-MB-231 (E) whole cell lysates.

Anti-KiSS1 receptor antibody - ab140839 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain cerebellum tissue, labeling KiSS1 receptor with ab140839 at 14 µg/ml.

Anti-KiSS1 receptor antibody - ab100896 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-KiSS1 receptor antibody (ab100896) at 1 µg/ml + Spinal Cord (Human) Tissue Lysate - adult normal tissue (ab29188) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KiSS1 receptor antibody - ab137483 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KiSS1 receptor antibody (ab137483) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : HeLa whole cell lysateLane 3 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-KiSS1 receptor antibody - C-terminal - ab188995 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded human tonsil tissue labeling KiSS1 receptor with ab188995 at 5 µg/ml.

Anti-KISS1R / GPR54 Antibody (aa375-396) - LS-C183894 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1R / GPR54 Antibody (aa375-396, Biotin) - LS-C183895 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KISS1R / GPR54 Antibody (aa375-396, Rhodamine) - LS-C183897 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KISS1R / GPR54 Antibody (aa375-396, CF) - LS-C183896 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KISS1R / GPR54 Antibody (aa375-398) - LS-C190877 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1R / GPR54 Antibody (aa301-350) - LS-C120732 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using KISS1R Antibody. The picture on the right is treated with the synthesized peptide.

Anti-KISS1R / GPR54 Antibody - LS-C341511 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KISS1R / GPR54 Antibody - LS-C109309 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: A431. B: Hela. C: Hep G2. 10% SDS PAGE. KISS1R antibody diluted at 1:1000.

Anti-KISS1R / GPR54 Antibody - LS-C109308 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: Hela. 10% SDS PAGE. KISS1R antibody diluted at 1:1000.

Anti-KISS1R / GPR54 Antibody - LS-C335283 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human ovarian cancer tissue using KISS1R antibody.

Anti-KISS1R / GPR54 Antibody (aa235-263) - LS-C203793 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
KISS1R Antibody western blot of HepG2 cell line lysates (35 ug/lane). The KISS1R antibody detected the KISS1R protein (arrow).

Anti-KISS1R / GPR54 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1927 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KISS1R / GPR54 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-KISS1R / GPR54 Antibody (N-Terminus) IHC-plus™ - LS-A1929 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KISS1R / GPR54 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-KISS1R / GPR54 Antibody (Extracellular Domain) IHC-plus™ - LS-A1926 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-KISS1R / GPR54 Antibody (C-Terminus) IHC-plus™ - LS-A1928 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KISS1R / GPR54 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A1928 dilution 3-5 ug/ml.

KiSS1R/GPR54 Antibody - NLS1926 from Novus Biologicals

Prices $369.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: KiSS1R/GPR54 Antibody [NLS1926] - Human Testis.

KiSS1R/GPR54 Antibody - NLS1929 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
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