KISS1R

Gene Symbol KISS1R
Entrez Gene 84634
Alt Symbol AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R
Species Human
Gene Type protein-coding
Description KISS1 receptor
Other Description G protein-coupled receptor 54|G-protein coupled receptor OT7T175|hypogonadotropin-1|kiSS-1 receptor|kisspeptins receptor|metastin receptor
Swissprots B2RTV1 A5D8U2 Q96QG0 Q969F8
Accessions CAH60299 CAH68808 EAW69583 Q969F8 AA887801 AB051065 BAB55446 AF343725 AAK83235 AJ309020 CAC40817 AY029541 AAK33126 AY253981 AAP82929 AY253982 AAP82930 BC140825 AAI40826 BC141812 AAI41813 CA432866 EU883577 ACG60651 NM_032551 NP_115940
Function Receptor for metastin (kisspeptin-54 or kp-54), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine- tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. {ECO:0000269|PubMed:15020672}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism. {ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:11387329, ECO:0000269|PubMed:11414709, ECO:0000269|PubMed:11457843, ECO:0000269|PubMed:12414911, ECO:0000269|PubMed:15020672}.
Top Pathways Neuroactive ligand-receptor interaction

GPR54 CRISPR/Cas9 KO Plasmid (h) - sc-403766 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR54 HDR Plasmid (h) - sc-403766-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR54 Double Nickase Plasmid (h) - sc-403766-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR54 Double Nickase Plasmid (h2) - sc-403766-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR54 CRISPR Activation Plasmid (h) - sc-403766-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR54 CRISPR Activation Plasmid (h2) - sc-403766-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR54 Lentiviral Activation Particles (h) - sc-403766-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR54 Lentiviral Activation Particles (h2) - sc-403766-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR54 siRNA (h) - sc-60747 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR54 shRNA Plasmid (h) - sc-60747-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR54 shRNA (h) Lentiviral Particles - sc-60747-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN2512 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2512 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01838 from Sigma-Aldrich

Category miRNA

KISS1R siRNA (Human) - CRJ3547 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KiSS1R/GPR54 RNAi - H00084634-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human KISS1R (NM_032551.4) - SHH325591 from Creative biogene

Category siRNA
Species Reactivities Human

Human KISS1R siRNA - orb274048 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KISS1R shRNA Plasmid (Human) - CHJ3547 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KISS1R miRNA 3'UTR clone - MiUTR3H-06603 from Creative biogene

Species Reactivities Human
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