| Gene Symbol | KISS1R |
|---|---|
| Entrez Gene | 84634 |
| Alt Symbol | AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R |
| Species | Human |
| Gene Type | protein-coding |
| Description | KISS1 receptor |
| Other Description | G protein-coupled receptor 54|G-protein coupled receptor OT7T175|hypogonadotropin-1|kiSS-1 receptor|kisspeptins receptor|metastin receptor |
| Swissprots | B2RTV1 A5D8U2 Q96QG0 Q969F8 |
| Accessions | CAH60299 CAH68808 EAW69583 Q969F8 AA887801 AB051065 BAB55446 AF343725 AAK83235 AJ309020 CAC40817 AY029541 AAK33126 AY253981 AAP82929 AY253982 AAP82930 BC140825 AAI40826 BC141812 AAI41813 CA432866 EU883577 ACG60651 NM_032551 NP_115940 |
| Function | Receptor for metastin (kisspeptin-54 or kp-54), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine- tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. {ECO:0000269|PubMed:15020672}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism. {ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:11387329, ECO:0000269|PubMed:11414709, ECO:0000269|PubMed:11457843, ECO:0000269|PubMed:12414911, ECO:0000269|PubMed:15020672}. |
| Top Pathways | Neuroactive ligand-receptor interaction |
Human KiSS1R/GPR54 (NP_115940) VersaClone cDNA - RDC0139 from R&D Systems
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Human KiSS1R/GRP54 (AAK83235) VersaClone cDNA - RDC0263 from R&D Systems
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Mouse KiSS1R/GPR54 (NP_444474) VersaClone cDNA - RDC0389 from R&D Systems
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Human KISS1R ORF clone(NM_032551.4) - CDCR005796 from Creative biogene
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