KISS1R

Gene Symbol	KISS1R
Entrez Gene	84634
Alt Symbol	AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R
Species	Human
Gene Type	protein-coding
Description	KISS1 receptor
Other Description	G protein-coupled receptor 54|G-protein coupled receptor OT7T175|hypogonadotropin-1|kiSS-1 receptor|kisspeptins receptor|metastin receptor
Swissprots	B2RTV1 A5D8U2 Q96QG0 Q969F8
Accessions	CAH60299 CAH68808 EAW69583 Q969F8 AA887801 AB051065 BAB55446 AF343725 AAK83235 AJ309020 CAC40817 AY029541 AAK33126 AY253981 AAP82929 AY253982 AAP82930 BC140825 AAI40826 BC141812 AAI41813 CA432866 EU883577 ACG60651 NM_032551 NP_115940
Function	Receptor for metastin (kisspeptin-54 or kp-54), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine- tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. {ECO:0000269|PubMed:15020672}.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism. {ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:11387329, ECO:0000269|PubMed:11414709, ECO:0000269|PubMed:11457843, ECO:0000269|PubMed:12414911, ECO:0000269|PubMed:15020672}.
Top Pathways	Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KISS1R / GPR54 ELISA Kit (Sandwich ELISA) - LS-F8306 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 0.313-20 ng/ml

Mouse KISS1R / GPR54 ELISA Kit (Sandwich ELISA) - LS-F8881 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 0.313-20 ng/ml

Rat KISS1R / GPR54 ELISA Kit (Sandwich ELISA) - LS-F8882 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.313-20 ng/ml

KiSS-1 receptor, KISS1R, Human, ELISA Kit - E2140h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 1.56-100 ng/mL

Kisspeptin Receptor (KISS1R), Human, ELISA Kit - SEF540Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.126ng/mL Range 0.312-20ng/mL

G-protein coupled receptor 54 (KiSS-1 receptor), ELISA Kit - MBS9304853 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G-protein coupled receptor 54 (KiSS-1 receptor), ELISA Kit - MBS9304965 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G-protein coupled receptor 54 (KiSS-1 receptor), ELISA Kit - MBS9305029 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

KISS1 receptor, ELISA Kit - MBS9338041 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Kisspeptin Receptor (KISS1R) - SEF540Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.126ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Kisspeptin Receptor (KISS1R) - SEF540Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Kisspeptin Receptor (KISS1R) - SEF540Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Kisspeptin Receptor (KISS1R) - SEF540Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.126ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Rat KISS1R / GPR54 ELISA Kit (Custom ELISA) - LS-F19346 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Mouse KISS1R / GPR54 ELISA Kit (Custom ELISA) - LS-F19345 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human KiSS-1 receptor ELISA Kit - abx251460 from Abbexa Category ELISA Kit Range 1.56 ng/ml - 100 ng/ml

Human KISS1R / GPR54 ELISA Kit (Sandwich ELISA) - LS-F13287 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 1.56 Range 0.313-20 ng/ml

Kisspeptin Receptor (KISS1R), Human, ELISA Kit - DL-KISS1R-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human KISS1R ELISA Kit - abx572816 from Abbexa Category ELISA Kit Sensitivity 0.126 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human KiSS-1 receptor ELISA Kit - EKE52608 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.78 ng/mL Range 1.56-100 ng/mL

KISS1R - EKH4252 from Nordic BioSite Sensitivity 0.938ng/ml Range 1.56-100ng/ml

KISS1R ELISA Kit (Human) : 96 Wells (OKEH01522) - OKEH01522 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.78 ng/mL Range 1.56 - 100 ng/mL

Human KiSS-1 receptor ELISA Kit - E015866 from Biobool Category ELISA Kit

Human KISS1R ELISA Kit - E021893 from Biobool Category ELISA Kit Sensitivity Typically less than 0.126ng/mL.

Human KiSS-1 receptor ELISA Kit - EK4324 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 21 pg/mL Range 0.156-10 ng/mL

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