PLAU

Gene Symbol	PLAU
Entrez Gene	5328
Alt Symbol	ATF, BDPLT5, QPD, UPA, URK, u-PA
Species	Human
Gene Type	protein-coding
Description	plasminogen activator, urokinase
Other Description	U-plasminogen activator\|plasminogen activator, urinary\|urokinase-type plasminogen activator
Swissprots	Q53XS3 Q16618 Q15844 Q5SWW9 B4DPZ2 P00749 Q969W6
Accessions	AAA61252 AAA61257 AAK53822 CAA01559 CAA26268 CAJ18774 CBX47479 EAW54544 EAW54545 P00749 A18397 CAA01390 A35395 CAA02215 AB208961 BAD92198 AK297940 BAG60256 AK298560 BAG60754 AK312960 BAG35799 AW316981 AY029537 AAK38734 AY820134 AAV70488 BC013575 AAH13575 BI759308 BI833559 BQ920793 BT007391 AAP36055 BX360462 CB959931 D00244 BAA00175 D11143 BAA01919 DC349055 DQ893817 ABM84743 K03226 AAC97138 M15476 AAA61253 X02760 CAA26535 Z36790 XM_011539866 XP_011538168 XM_011539867 XP_011538169 NM_001145031 NP_001138503 NM_002658 NP_002649
Function	Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Subcellular Location	Secreted.
Tissue Specificity	Expressed in the prostate gland and prostate cancers. {ECO:0000269\|PubMed:15988036}.
Top Pathways	Complement and coagulation cascades, MicroRNAs in cancer, Proteoglycans in cancer, Transcriptional misregulation in cancer

uPA (C-20) - sc-6830 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Western blot analysis of authentic human uPA. Antibodies tested include uPA (C-20): sc-6830 (A) and uPA (M-20): sc-6831 (B).

uPA (H-140) - sc-14019 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

uPA siRNA (h): sc-36779. Western blot analysis of uPA expression in non-transfected control (A) and uPA siRNA transfected (B) HeLa cells. Blot probed with uPA (H-140): sc-14019. GAPDH (FL-335): sc-25778 used as specificity and loading control.

uPA (M-20) - sc-6831 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

uPA (PGM2001) - sc-59728 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

uPA (PGM2005) - sc-59729 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

Anti-uPA antibody [EP6274(2)] - ab169754 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP6274(2)

Anti-uPA antibody [EP6274(2)] (ab169754) at 1/1000 dilution + PC3 cell lysate at 10 µg

Anti-uPA antibody [U-16] - ab131433 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	U-16

Overlay histogram showing HT1080 cells stained with ab131433 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab131433, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HT1080 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Urokinase antibody - ab24121 from Abcam

Prices	$394.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

ICC/IF image of ab24121 stained DU145 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab24121 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Urokinase antibody - ab24122 from Abcam

Host	Goat
Clonality	Polyclonal

ICC/IF image of ab24122 stained DU145 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA /0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab24122 at 10µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 donkey anti- goat (ab96931) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Urokinase antibody - ab197355 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling Urokinase using ab197355 at 1/10 dilution.

Anti-Urokinase antibody - ab14195 from Abcam

Host	Goat
Clonality	Polyclonal

Anti-Urokinase antibody - ab40841 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-Urokinase antibody (ab40841) at 0.3 µg/ml + 293 lysate (35µg protein in RIPA buffer).

Anti-Urokinase antibody - ab20046 from Abcam

Prices	$372.00
Sizes	500 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Urokinase antibody - ab109055 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Urokinase antibody (ab109055) at 1 µg/mlLane 1 : Prostate (Human) Whole Cell Lysate - liver cirrhosis (ab30307)Lane 2 : Thyroid (Human) Whole Cell Lysate - adult normal tissue (ab29636)Lane 3 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Urokinase antibody - ab48596 from Abcam

Prices	$370.00
Sizes	150 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Urokinase antibody [3A108] (FITC) - ab170078 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3A108

Anti-Urokinase antibody (Biotin) - ab49577 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Urokinase antibody [EPR6273] - ab133563 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR6273

All lanes : Anti-Urokinase antibody [EPR6273] (ab133563) at 1/100 dilution (unpurified)Lane 1 : LnCap cell lysateLane 2 : PC-3 cell lysateLysates/proteins at 10 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-Urokinase antibody (FITC) - ab28223 from Abcam

Prices	$370.00
Sizes	200 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Urokinase antibody [H77A10] - ab28230 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	H77A10

All lanes : Anti-Urokinase antibody [H77A10] (ab28230) at 3 µg/mlLane 1 : Mouse Urokinase (0.5ug)Lane 2 : MUPA (0.5ug) + CPAI (2.5ug)Lane 3 : Prestained standardPerformed under non-reducing conditions.

Anti-Urokinase antibody [PGM2001] - ab8475 from Abcam

Prices	$382.00
Sizes	200 µg
Host	Mouse
Clonality	Monoclonal
Clone	PGM2001

Anti-Urokinase antibody [PGM2005] - ab8473 from Abcam

Host	Mouse
Clonality	Monoclonal
Clone	PGM2005

Anti-Urokinase antibody [U-6] - ab82250 from Abcam

Prices	$372.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	U-6

Anti-PLAU / Urokinase / uPA Antibody - LS-C3411 from LifeSpan Bioscience

Prices	$365.00
Sizes	1 mg
Host	Rabbit
Clonality	Polyclonal

Anti-PLAU / Urokinase / uPA Antibody - LS-C3410 from LifeSpan Bioscience

Prices	$415.00
Sizes	1 mg
Host	Rabbit
Clonality	Polyclonal

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