SETDB1

Gene Symbol	SETDB1
Entrez Gene	9869
Alt Symbol	ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21
Species	Human
Gene Type	protein-coding
Description	SET domain, bifurcated 1
Other Description	ERG-associated protein with SET domain|ERG-associated protein with a SET domain, ESET|H3-K9-HMTase 4|histone H3-K9 methyltransferase 4|histone-lysine N-methyltransferase SETDB1|histone-lysine N-methyltransferase, H3lysine-9 specific 4|lysine N-methyltransferase 1E|tudor domain containing 21
Swissprots	Q96GM9 Q5SZE0 A6NEW2 Q5SZD9 Q15047 Q5SZE7 Q5SZD8
Accessions	CBJ06473 CBJ06474 EAW53503 EAW53504 EAW53505 EAW53506 EAW53507 EAW53508 Q15047 AI582266 AK095075 AK302461 BAG63752 AK308335 BC009362 AAH09362 BC028671 AAH28671 D31891 BAA06689 DA418593 DB062762 XM_005245641 XP_005245698 NM_001145415 NP_001138887 NM_001243491 NP_001230420 NM_012432 NP_036564
Function	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. {ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:15327775, ECO:0000269|PubMed:17952062}.
Subcellular Location	Nucleus. Chromosome. Note=Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin.
Tissue Specificity	Widely expressed. High expression in testis.
Top Pathways	Signaling pathways regulating pluripotency of stem cells, Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SETDB1 293T Cell Transient Overexpression Lysate(Denatured) - H00009869-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SETDB1 overexpression lysate - LY402212 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SETDB1 overexpression lysate - LY428874 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

SETDB1 293 Cell Lysate - 401946 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SETDB1 Overexpression Lysate (Denatured) - H00009869-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

SETDB1 Overexpression Lysate (Native) - NBL1-15871 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SETDB1 Over-expression Lysate Product - GWB-5C306C from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

SETDB1 Overexpression Lysate (Native) - NBP2-09749 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human SETDB1 Knockdown Stable Cell Line - CSC-DC014087 from Creative biogene Category Cell Line Species Human

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