SETDB1

Gene Symbol	SETDB1
Entrez Gene	9869
Alt Symbol	ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21
Species	Human
Gene Type	protein-coding
Description	SET domain, bifurcated 1
Other Description	ERG-associated protein with SET domain|ERG-associated protein with a SET domain, ESET|H3-K9-HMTase 4|histone H3-K9 methyltransferase 4|histone-lysine N-methyltransferase SETDB1|histone-lysine N-methyltransferase, H3lysine-9 specific 4|lysine N-methyltransferase 1E|tudor domain containing 21
Swissprots	Q96GM9 Q5SZE0 A6NEW2 Q5SZD9 Q15047 Q5SZE7 Q5SZD8
Accessions	CBJ06473 CBJ06474 EAW53503 EAW53504 EAW53505 EAW53506 EAW53507 EAW53508 Q15047 AI582266 AK095075 AK302461 BAG63752 AK308335 BC009362 AAH09362 BC028671 AAH28671 D31891 BAA06689 DA418593 DB062762 XM_005245641 XP_005245698 NM_001145415 NP_001138887 NM_001243491 NP_001230420 NM_012432 NP_036564
Function	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. {ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:15327775, ECO:0000269|PubMed:17952062}.
Subcellular Location	Nucleus. Chromosome. Note=Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin.
Tissue Specificity	Widely expressed. High expression in testis.
Top Pathways	Signaling pathways regulating pluripotency of stem cells, Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KMT1E / SETDB1 protein fragment - ab153023 from Abcam Category Protein Source Wheat germ Species Human

Human KMT1E / SETDB1 protein fragment - ab153024 from Abcam Category Protein Source Wheat germ Species Human

ESET / SETDB1 Antibody Blocking Peptide - LS-E456 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SETDB1 Protein - H00009869-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SETDB1 Protein - H00009869-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SETDB1-Antibody-C-term-Blocking-Peptide - BP1073b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SETDB1 - H00009869-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SETDB1 - H00009869-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SETDB1 - H00009869-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SETDB1 - H00009869-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SETDB1 fusion protein - Ag21644 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SETDB1 fusion protein - ag1725 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant SETDB1 protein - 31452 from ActiveMotif Category Protein Prices $425.00 Sizes 20 µg Source Baculovirus Species Human

Recombinant Human SETDB1, FLAG-tagged - SETDB1-70H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human Histone-lysine N-methyltransferase SETDB1(SETDB1) ,partial - CSB-YP619960HU CSB-EP619960HU CSB-BP619960HU CSB-MP619960HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SETDB1 (transcript variant 2) - TP303647 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SETDB1 (transcript variant 1) - TP326620 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Histone H3, trimethyl, Peptide - MBS659152 from MyBioSource Category Peptide Prices $265.00 Sizes 100 µg

SETDB1 Recombinant Protein Antigen - NBP1-84790PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SETDB1-Antibody-N-term-Blocking-Peptide - BP1073a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SETDB1 Peptide, Human - M34GP14087H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human SETDB1 protein - orb54306 from Biorbyt Category Protein Prices $289.00, $408.00, $476.00, $765.00, $1,275.00, $2,023.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

Histone-lysine N-methyltransferase SETDB1 (SETDB1), partial, Recombinant Protein - MBS1423750 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SETDB1, Recombinant Protein - MBS515672 from MyBioSource Category Protein Prices $325.00, $500.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

SETDB1 Recombinant Protein (Human) (OPCA04793) - OPCA04793 from Aviva Systems Biology Category Protein Species Human

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