SETDB1

Gene Symbol SETDB1
Entrez Gene 9869
Alt Symbol ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21
Species Human
Gene Type protein-coding
Description SET domain, bifurcated 1
Other Description ERG-associated protein with SET domain|ERG-associated protein with a SET domain, ESET|H3-K9-HMTase 4|histone H3-K9 methyltransferase 4|histone-lysine N-methyltransferase SETDB1|histone-lysine N-methyltransferase, H3lysine-9 specific 4|lysine N-methyltransferase 1E|tudor domain containing 21
Swissprots Q96GM9 Q5SZE0 A6NEW2 Q5SZD9 Q15047 Q5SZE7 Q5SZD8
Accessions CBJ06473 CBJ06474 EAW53503 EAW53504 EAW53505 EAW53506 EAW53507 EAW53508 Q15047 AI582266 AK095075 AK302461 BAG63752 AK308335 BC009362 AAH09362 BC028671 AAH28671 D31891 BAA06689 DA418593 DB062762 XM_005245641 XP_005245698 NM_001145415 NP_001138887 NM_001243491 NP_001230420 NM_012432 NP_036564
Function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. {ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:15327775, ECO:0000269|PubMed:17952062}.
Subcellular Location Nucleus. Chromosome. Note=Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin.
Tissue Specificity Widely expressed. High expression in testis.
Top Pathways Signaling pathways regulating pluripotency of stem cells, Lysine degradation

ESET CRISPR/Cas9 KO Plasmid (h) - sc-401325 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESET HDR Plasmid (h) - sc-401325-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESET Double Nickase Plasmid (h) - sc-401325-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESET Double Nickase Plasmid (h2) - sc-401325-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESET CRISPR Activation Plasmid (h) - sc-401325-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESET CRISPR Activation Plasmid (h2) - sc-401325-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESET Lentiviral Activation Particles (h) - sc-401325-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESET Lentiviral Activation Particles (h2) - sc-401325-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESET siRNA (h) - sc-45659 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ESET shRNA Plasmid (h) - sc-45659-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ESET shRNA (h) Lentiviral Particles - sc-45659-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SETDB1 RNAi - H00009869-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU046261 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19174 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19174 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SETDB1 siRNA (Human) - CRH6618 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SETDB1 - MBS8202235 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SETDB1 shRNA Plasmid (Human) - CHH6618 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SETDB1 miRNA 3'UTR clone - MiUTR3H-06768 from Creative biogene

Species Reactivities Human

SETDB1 miRNA 3'UTR clone - MiUTR3H-06769 from Creative biogene

Species Reactivities Human
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