| Gene Symbol |
MARCKSL1
|
| Entrez Gene |
65108
|
| Alt Symbol |
F52, MACMARCKS, MLP, MLP1, MRP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MARCKS-like 1
|
| Other Description |
MARCKS-like protein 1|MARCKS-related protein|mac-MARCKS|macrophage myristoylated alanine-rich C kinase substrate
|
| Swissprots |
Q5TEE6 D3DPQ0 Q6NXS5 P49006
|
| Accessions |
AAP37955 EAX07537 EAX07538 EAX07539 P49006 AI879076 AL713653 CAD28462 AM393505 CAL38382 AY007131 BC007904 AAH07904 BC066915 AAH66915 DQ893237 ABM84163 DQ896567 ABM87566 DT218825 N70661 X70326 CAA49793 NM_023009 NP_075385 NR_052852
|
| Function |
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity). In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity). {ECO:0000250}.
|
| Top Pathways |
Fc gamma R-mediated phagocytosis, Leishmaniasis
|